Private Practice, Lymington, Hampshire SO41 9AH, UK.
Int J Environ Res Public Health. 2022 Dec 7;19(24):16400. doi: 10.3390/ijerph192416400.
Cutaneous warts are common lesions in children caused by the Human Papilloma Virus (HPV) and for most lesions spontaneously resolve within months of the initial infection, regardless of treatment. The infection is most prevalent in the second decade of life affecting over 40% of children. Studies have demonstrated wart virus carriage on normal skin is higher in children with active lesions and family members. Subtypes HPV 2, HPV 27, HPV 57 and HPV 63 are particularly common in paediatric populations. Warts arising on the plantar surface of the foot (verrucae) can be particularly problematic owing to the location. They may interfere with daily activities causing pain and embarrassment. Plantar lesions have been shown to be more resistant to treatment than warts elsewhere on the skin. Systematic reviews and studies conducted over the last decade have demonstrated little evidence of innovation or effective improvements in treatment of recalcitrant lesions over the last 30 years. However, newer modalities such as immunotherapy (using injected vaccines) and hyperthermia using microwave treatment may hold promise in improving the treatment of these common and therapeutically frustrating lesions.
皮肤疣是儿童常见的病变，由人乳头瘤病毒（HPV）引起，大多数病变在初次感染后的数月内会自行消退，无论是否治疗。感染在生命的第二个十年最为普遍，超过 40%的儿童受到影响。研究表明，在有活动性病变和家庭成员的儿童中，正常皮肤上的疣病毒携带率更高。HPV 2 型、HPV 27 型、HPV 57 型和 HPV 63 型在儿科人群中尤为常见。足底（跖疣）上的疣由于位置特殊，可能会特别成问题。它们可能会干扰日常生活，导致疼痛和尴尬。研究表明，足底病变比皮肤其他部位的疣更难治疗。过去十年进行的系统评价和研究表明，在过去 30 年中，对于顽固病变的治疗，几乎没有创新或有效的改进证据。然而，免疫疗法（使用注射疫苗）和微波热疗等新方法可能有望改善这些常见且治疗效果令人沮丧的病变的治疗效果。
