El-Tonsy M H, Anbar T E, El-Domyati M, Barakat M
Department of Dermatology, al-Minya University Hospital, Egypt.
Int J Dermatol. 1999 May;38(5):393-8. doi: 10.1046/j.1365-4362.1999.00719.x.
Warts often present a difficult treatment problem for clinicians because of the lack of specific antipapillomavirus agents. Plantar warts, in particular, represent a therapeutic challenge.
Twenty-five patients with plantar warts were treated with Nd:YAG hyperthermia and another 25 were treated with cryotherapy. Biopsies were taken before and after treatment in both groups and were examined for the presence of human papillomavirus deoxyribonucleic acid (HPV DNA) using in situ hybridization (ISH).
HPV DNA was detected in 100% of untreated warts and in 96% of cryotreated warts, but was not detected in any of the hyperthermia-treated warts.
HPV is more vulnerable to hyperthermia than to cryotherapy.
由于缺乏特异性抗乳头瘤病毒药物，疣常常给临床医生带来治疗难题。尤其是跖疣，更是一项治疗挑战。
25例跖疣患者接受钕钇铝石榴石激光热疗，另外25例接受冷冻疗法。两组患者在治疗前后均进行活检，并使用原位杂交（ISH）检测人乳头瘤病毒脱氧核糖核酸（HPV DNA）的存在情况。
100%的未治疗疣和96%的冷冻治疗疣中检测到HPV DNA，但在任何热疗治疗的疣中均未检测到。
HPV对热疗比对冷冻疗法更敏感。
