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血浆抗CD4 IgG水平与开始抗逆转录病毒治疗的HIV感染者免疫恢复不佳有关。

Plasma anti-CD4 IgG levels are associated with poor immune recovery in people with HIV initiating antiretroviral therapy.

作者信息

Bowler Scott A, Premeaux Thomas A, Ratzan Leo, Friday Courtney, Gianella Sara, Landay Alan L, Ndhlovu Lishomwa C

机构信息

Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY.

Division of Infectious Diseases, Department of Medicine, University of California San Diego, San Diego, CA.

出版信息

AIDS. 2025 Feb 1;39(2):208-210. doi: 10.1097/QAD.0000000000004044. Epub 2025 Jan 2.

DOI:10.1097/QAD.0000000000004044
PMID:39787486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11731887/
Abstract

A segment of people with HIV on effective antiretroviral therapy (ART) continue to experience poor immune recovery, leaving them at heightened risk of non-AIDS-defining events (NAEs). The production of anti-CD4 IgG autoreactive antibodies is suggested as one contributing mechanism to these complications. Here, we found that plasma anti-CD4 levels do not discriminate immunological responders from nonresponders nor predict the occurrence of NAEs, suggesting it is unlikely a contributing immunopathological factor associated with these complications.

摘要

一部分接受有效抗逆转录病毒疗法（ART）的艾滋病毒感染者的免疫功能仍持续恢复不佳，这使他们面临发生非艾滋病定义事件（NAEs）的更高风险。抗CD4 IgG自身反应性抗体的产生被认为是导致这些并发症的一种机制。在此，我们发现血浆抗CD4水平既不能区分免疫应答者和无应答者，也无法预测NAEs的发生，这表明它不太可能是与这些并发症相关的免疫病理因素。

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本文引用的文献

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Machine learning models based on fluid immunoproteins that predict non-AIDS adverse events in people with HIV.基于体液免疫蛋白的机器学习模型可预测艾滋病毒感染者的非艾滋病不良事件。
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Measures of Longitudinal Immune Dysfunction and Risk of AIDS and Non-AIDS Defining Malignancies in Antiretroviral-Treated People With Human Immunodeficiency Virus.抗逆转录病毒治疗的人类免疫缺陷病毒感染者纵向免疫功能障碍指标与艾滋病和非艾滋病定义的恶性肿瘤风险
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AIDS. 2023 Mar 1;37(3):554-555. doi: 10.1097/QAD.0000000000003430.
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The Prevalence of HIV-infected Patients with Virological Suppression but a CD4 T-cell Count of ≤ 200 Cells/mm after Highly Active Antiretroviral Therapy Initiation: A Meta-analysis.高效抗逆转录病毒治疗启动后病毒学抑制但 CD4 T 细胞计数≤200 个/立方毫米的 HIV 感染患者的流行率：一项荟萃分析。
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