Department of Tropical Medicine, University of Hawai'i, Honolulu, HI, USA.
Department of Quantitative Health Sciences, University of Hawai'i, Honolulu, HI, USA.
J Neurovirol. 2021 Apr;27(2):334-339. doi: 10.1007/s13365-021-00966-0. Epub 2021 Mar 12.
Anti-CD4 IgG autoantibodies have been implicated in CD4 T cell reconstitution failure, leaving people with HIV (PWH) at heightened risk of HIV-associated comorbidities, such as neurocognitive impairment. Seventeen PWH on stable anti-retroviral therapy (ART) and 10 HIV seronegative controls had plasma anti-CD4 IgG antibodies measured by enzyme-linked immunosorbent assay. Neuropsychological (NP) tests assessed cognitive performance, and brain volumes were measured by structural magnetic resonance imaging. Anti-CD4 IgG levels were elevated (p = 0.04) in PWH compared with controls. Anti-CD4 IgG correlated with global NP z-scores (rho = - 0.51, p = 0.04). A relationship was observed between anti-CD4 IgG and putamen (β = - 0.39, p = 0.02), pallidum (β = - 0.38, p = 0.03), and amygdala (β = - 0.42, p = 0.05) regional brain volumes. The results of this study suggest the existence of an antibody-mediated relationship with neurocognitive impairment and brain abnormalities in an HIV-infected population.
抗 CD4 IgG 自身抗体与 CD4 T 细胞重建失败有关，使 HIV 感染者（PWH）面临更高的 HIV 相关合并症风险，如神经认知障碍。17 名接受稳定抗逆转录病毒治疗（ART）的 PWH 和 10 名 HIV 血清阴性对照者通过酶联免疫吸附试验测量血浆抗 CD4 IgG 抗体。神经心理学（NP）测试评估认知表现，结构磁共振成像测量脑容量。与对照组相比，PWH 的抗 CD4 IgG 水平升高（p=0.04）。抗 CD4 IgG 与全球 NP z 分数呈负相关（rho=-0.51，p=0.04）。观察到抗 CD4 IgG 与壳核（β=-0.39，p=0.02）、苍白球（β=-0.38，p=0.03）和杏仁核（β=-0.42，p=0.05）的脑区体积之间存在关系。本研究结果表明，在 HIV 感染人群中，存在一种与神经认知障碍和脑异常相关的抗体介导关系。
