Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició Humana, C/Sant Llorenç 21, 43201, Reus, Spain.
Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari San Joan de Reus, 43204, Reus, Spain.
Eur J Nutr. 2021 Dec;60(8):4367-4378. doi: 10.1007/s00394-021-02585-1. Epub 2021 May 28.
We evaluated whether the intake of dietary vitamin D is associated with the incidence of both colorectal cancer (CRC) and colon cancer in the framework of the PREDIMED cohort of older adults at high cardiovascular risk.
We analyzed data from 7216 men and women (55-80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Baseline consumption of vitamin D was assessed using a validated 137-item food frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC and colon cancer incidence were estimated for quartiles and per 1-SD of baseline vitamin D intake.
During a median follow-up of 6 years, we documented 97 incident CRC cases after the exclusion of subjects with no baseline dietary data and/or outliers of energy intake. A non-significant HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme quartiles (4th vs 1st) of vitamin D intake were observed [0.55 (0.30-1.00), P for trend = 0.072], whereas it was significant for colon cancer incidence alone [0.44 (0.22-0.90), P for trend = 0.032]. However, this association became significant in CRC and colon cancer incidence, after excluding 391 subjects consuming baseline vitamin D and/or calcium medication or prescribed supplements [0.52 (0.28-0.96) and 0.41 (0.12-0.85), respectively].
A higher dietary intake of vitamin D was significantly associated with a reduced CRC risk in individuals at high cardiovascular risk.
我们评估了在高心血管风险的 PRE-DIMED 队列中，饮食中维生素 D 的摄入量是否与结直肠癌（CRC）和结肠癌的发病率有关。
我们分析了来自 PREVENCIÓN CON DIETA MEDITERRÁNEA 研究的 7216 名无基线 CRC 的男性和女性（55-80 岁）的数据。使用经过验证的 137 项食物频率问卷评估基线时维生素 D 的摄入量。使用 Cox 比例风险比（HRs）估计 CRC 和结肠癌发病率的四分位数和基线维生素 D 摄入量的每 1-SD。
在中位 6 年的随访期间，在排除了没有基线饮食数据和/或能量摄入异常的受试者后，我们记录了 97 例 CRC 病例。维生素 D 摄入量的极端四分位数（第 4 与第 1 分位）之间 CRC 的 HRs 和 95%置信区间（CI）无显著性差异[0.55（0.30-1.00），趋势 P=0.072]，而单独对结肠癌发生率则有显著性差异[0.44（0.22-0.90），趋势 P=0.032]。然而，在排除了 391 名基线时服用维生素 D 和/或钙药物或处方补充剂的受试者后，这种关联在 CRC 和结肠癌的发病率中变得显著[0.52（0.28-0.96）和 0.41（0.12-0.85）]。
在高心血管风险的个体中，较高的饮食维生素 D 摄入量与降低 CRC 风险显著相关。
