中国健康与养老追踪调查中平衡功能障碍与运动认知风险综合征发病率之间的关联
Association between balance impairment and incidence of motoric cognitive risk syndrome in the China Health and Retirement Longitudinal Study.
作者信息
Xu Zhigang, Jia Shuli, Huang Ning, Ma Ya, Qin Dan, Dong Birong
机构信息
The Center of Gerontology and Geriatrics and National Clinical Research Center of Geriatrics, West China Hospital, Sichuan University, China; The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, China.
The Center of Gerontology and Geriatrics and National Clinical Research Center of Geriatrics, West China Hospital, Sichuan University, China.
出版信息
J Nutr Health Aging. 2025 Mar;29(3):100476. doi: 10.1016/j.jnha.2024.100476. Epub 2025 Jan 8.
OBJECTIVES
Motor cognitive risk (MCR) syndrome, defined as the cooccurrence of subjective cognitive complaints and a slow gait speed, is a form of pre-dementia condition. Balance has previously been associated with cognitive function. However, to date, no study has examined the relationship between balance and MCR in a large cohort of older adults. We aimed to investigate the associations of balance with MCR among Chinese older adults.
RESEARCH DESIGN AND METHODS
Data from the wave 1 to wave 3 of the China Health and Retirement Longitudinal Study (CHARLS) were used. Balance was measured using validated tandem stance. Logistic and discrete-time survival cox regression analyses were performed to examine the relationship between baseline balance impairment and prevalent and incident MCR.
RESULTS
A total of 3,398 participants were included in the baseline study. The prevalence of balance impairment was 21.1%. In the cross-sectional analysis, balance impairment was significantly associated with higher odds of MCR in the fully-adjusted model (OR: 1.43 95%CI 1.14-1.80, p = 0.002). A total of 2,474 individuals were included in the longitudinal analysis. During a mean follow-up duration of 3.69 years, the incidence of MCR was 9.8%. Baseline balance impairment was also significantly related to incidence of MCR (HR:1.37 95%CI 1.03-1.82, p = 0.032) even adjusting all confounders.
CONCLUSION
These results show that early recognition of balance disorder may be helpful in the prevention and treatment of cognitive decline in older adults.
目的
运动认知风险（MCR）综合征被定义为主观认知主诉与步态速度缓慢同时出现，是一种痴呆前期状态。平衡能力此前已被证明与认知功能相关。然而，迄今为止，尚无研究在大量老年人群体中考察平衡能力与MCR之间的关系。我们旨在调查中国老年人群体中平衡能力与MCR之间的关联。
研究设计与方法
使用了中国健康与养老追踪调查（CHARLS）第1轮至第3轮的数据。采用经过验证的串联站立测试来测量平衡能力。进行逻辑回归和离散时间生存Cox回归分析，以检验基线平衡能力受损与现患和新发MCR之间的关系。
结果
共有3398名参与者纳入基线研究。平衡能力受损的患病率为21.1%。在横断面分析中，在完全调整模型中，平衡能力受损与MCR的较高几率显著相关（比值比：1.43，95%置信区间1.14 - 1.80，p = 0.002）。共有2474人纳入纵向分析。在平均3.69年的随访期间，MCR的发病率为9.8%。即使调整所有混杂因素后，基线平衡能力受损也与MCR的发病率显著相关（风险比：1.37，95%置信区间1.03 - 1.82，p = 0.032）。
结论
这些结果表明，早期识别平衡障碍可能有助于预防和治疗老年人的认知衰退。
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