Xu Zhigang, Jia Shuli, Huang Ning, Ma Ya, Qin Dan, Dong Birong
The Center of Gerontology and Geriatrics and National Clinical Research Center of Geriatrics, West China Hospital, Sichuan University, China; The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, China.
The Center of Gerontology and Geriatrics and National Clinical Research Center of Geriatrics, West China Hospital, Sichuan University, China.
J Nutr Health Aging. 2025 Mar;29(3):100476. doi: 10.1016/j.jnha.2024.100476. Epub 2025 Jan 8.
Motor cognitive risk (MCR) syndrome, defined as the cooccurrence of subjective cognitive complaints and a slow gait speed, is a form of pre-dementia condition. Balance has previously been associated with cognitive function. However, to date, no study has examined the relationship between balance and MCR in a large cohort of older adults. We aimed to investigate the associations of balance with MCR among Chinese older adults.
Data from the wave 1 to wave 3 of the China Health and Retirement Longitudinal Study (CHARLS) were used. Balance was measured using validated tandem stance. Logistic and discrete-time survival cox regression analyses were performed to examine the relationship between baseline balance impairment and prevalent and incident MCR.
A total of 3,398 participants were included in the baseline study. The prevalence of balance impairment was 21.1%. In the cross-sectional analysis, balance impairment was significantly associated with higher odds of MCR in the fully-adjusted model (OR: 1.43 95%CI 1.14-1.80, p = 0.002). A total of 2,474 individuals were included in the longitudinal analysis. During a mean follow-up duration of 3.69 years, the incidence of MCR was 9.8%. Baseline balance impairment was also significantly related to incidence of MCR (HR:1.37 95%CI 1.03-1.82, p = 0.032) even adjusting all confounders.
These results show that early recognition of balance disorder may be helpful in the prevention and treatment of cognitive decline in older adults.
运动认知风险（MCR）综合征被定义为主观认知主诉与步态速度缓慢同时出现，是一种痴呆前期状态。平衡能力此前已被证明与认知功能相关。然而，迄今为止，尚无研究在大量老年人群体中考察平衡能力与MCR之间的关系。我们旨在调查中国老年人群体中平衡能力与MCR之间的关联。
使用了中国健康与养老追踪调查（CHARLS）第1轮至第3轮的数据。采用经过验证的串联站立测试来测量平衡能力。进行逻辑回归和离散时间生存Cox回归分析，以检验基线平衡能力受损与现患和新发MCR之间的关系。
共有3398名参与者纳入基线研究。平衡能力受损的患病率为21.1%。在横断面分析中，在完全调整模型中，平衡能力受损与MCR的较高几率显著相关（比值比：1.43，95%置信区间1.14 - 1.80，p = 0.002）。共有2474人纳入纵向分析。在平均3.69年的随访期间，MCR的发病率为9.8%。即使调整所有混杂因素后，基线平衡能力受损也与MCR的发病率显著相关（风险比：1.37，95%置信区间1.03 - 1.82，p = 0.032）。
这些结果表明，早期识别平衡障碍可能有助于预防和治疗老年人的认知衰退。
