Whittle James R, Kriel Jurgen, Fatunla Oluwaseun E, Lu Tianyao, Moffet Joel J D, Spiteri Montana, Best Sarah A, Freytag Saskia
Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia; Department of Medical Biology, University of Melbourne, Melbourne, Australia; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia; Department of Medical Biology, University of Melbourne, Melbourne, Australia.
Semin Cell Dev Biol. 2025 Mar;167:1-9. doi: 10.1016/j.semcdb.2024.12.006. Epub 2025 Jan 8.
The glioblastoma tumour microenvironment is characterised by immense heterogeneity, with malignant and non-malignant cells that interact in a complex ecosystem. Emerging evidence suggests that the tumour microenvironment is key in facilitating rapid proliferation, invasion, migration and cancer cell survival, crucial for treatment resistance. Spatial omics technologies have enabled the molecular characterisation of regions or individual cells within their spatial context, providing previously unattainable insights into the complex organisation of the glioblastoma tumour microenvironment. Understanding this organisation is crucial for the development of new therapeutics and novel diagnostic tools that guide patient care. This review explores spatial omics technologies and how they have contributed to the development of a model outlining the architecture of the glioblastoma tumour microenvironment.
胶质母细胞瘤的肿瘤微环境具有极大的异质性，其中恶性和非恶性细胞在一个复杂的生态系统中相互作用。新出现的证据表明，肿瘤微环境是促进癌细胞快速增殖、侵袭、迁移和存活的关键因素，对治疗耐药性至关重要。空间组学技术能够在空间背景下对区域或单个细胞进行分子表征，为胶质母细胞瘤肿瘤微环境的复杂组织提供了前所未有的见解。了解这种组织对于开发指导患者护理的新疗法和新型诊断工具至关重要。本综述探讨了空间组学技术，以及它们如何为构建胶质母细胞瘤肿瘤微环境结构模型做出贡献。
