产志贺毒素大肠杆菌黏附素——善恶之间的微妙界限。

pksE. coli adhesins-The fine line between good and evil.

作者信息

Wong Chi Chun, Yu Jun

机构信息

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.

出版信息

Cell Host Microbe. 2025 Jan 8;33(1):1-3. doi: 10.1016/j.chom.2024.12.007.

DOI:10.1016/j.chom.2024.12.007

PMID:39788090

Abstract

Gut bacteria could promote colorectal cancer by generating genotoxins. In a recent issue of Nature, Jans et al. identified bacterial adhesion as an additional determinant for the genotoxic activity of colibactin-producing E. coli on the colon epithelium, which could be targeted to mitigate bacteria-associated DNA damage.

摘要

肠道细菌可通过产生基因毒素促进结直肠癌。在最近一期的《自然》杂志上，扬斯等人确定细菌黏附是产大肠杆菌素的大肠杆菌对结肠上皮细胞基因毒性活性的另一个决定因素，这一因素可作为减轻细菌相关DNA损伤的靶点。