Wang Xiaoqian, Chen Xiaotian, Jiang Fengjuan, Cheng Yongqing, Li Yuan
Department of Clinical Nutrition, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Department of Clinical Nutrition, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Int J Cardiol. 2025 Mar 1;422:132974. doi: 10.1016/j.ijcard.2025.132974. Epub 2025 Jan 7.
The consumption of trans fatty acids (TFAs) increases the risk of heart disease morbidity and mortality. However, the relationship between measurable indicators of TFAs and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in general population remains unclear.
1478 adult participants with complete information on circulating TFA and NT-proBNP levels from National Health and Nutrition Examination Survey (NHANES) 1999-2000 were included in our cross-sectional survey. Smooth curve fitting, multivariable linear regression and binary logistic regression were performed to analyze the relationship between TFAs and NT-proBNP. We also conducted stratified analyses and interaction terms to explore the potential modifiers of the association.
Participants were grouped by quartiles of NT-proBNP levels. One-way ANOVA indicated significant differences in the plasma TFA concentrations across the groups. The smooth curve fitting diagram confirmed a significant linear relationship between TFAs and NT-proBNP. Multivariable linear regression analysis revealed that palmitelaidic acid, elaidic acid, vaccenic acid, linolelaidic acid and total TFAs was linearly and positively related to NT-proBNP. Stratified analyses and the interaction test showed that age, sex, and BMI did not affect the relation between them (P value for interaction >0.05). The results of binary logistic regression indicated that participants who were in higher quartiles of elaidic acid, vaccenic acid, linolelaidic acid and total TFAs showed a higher prevalence of elevated NT-proBNP.
In a national sample of adults, circulating TFAs, regardless of their industrial or ruminant origin, were positively associated with NT-proBNP.
反式脂肪酸（TFA）的摄入会增加心脏病发病和死亡风险。然而，普通人群中TFA的可测量指标与N端前脑钠肽（NT-proBNP）之间的关系仍不明确。
我们的横断面调查纳入了1999 - 2000年美国国家健康与营养检查调查（NHANES）中1478名有循环TFA和NT-proBNP水平完整信息的成年参与者。进行了平滑曲线拟合、多变量线性回归和二元逻辑回归分析TFA与NT-proBNP之间的关系。我们还进行了分层分析和交互项分析以探索该关联的潜在修饰因素。
参与者按NT-proBNP水平四分位数分组。单因素方差分析表明各组间血浆TFA浓度存在显著差异。平滑曲线拟合图证实了TFA与NT-proBNP之间存在显著线性关系。多变量线性回归分析显示，棕榈油酸、反油酸、vaccenic酸、亚油酸和总TFA与NT-proBNP呈线性正相关。分层分析和交互检验表明，年龄、性别和BMI不影响它们之间的关系（交互作用P值>0.05）。二元逻辑回归结果表明，反油酸、vaccenic酸、亚油酸和总TFA处于较高四分位数的参与者NT-proBNP升高的患病率更高。
在全国成人样本中，无论其工业来源还是反刍动物来源，循环TFA均与NT-proBNP呈正相关。
