对比增强磁共振成像（MRI）图像与非对比MRI图像之间脑容量测量的比较分析。
Comparative analysis of brain volumetric measurements between contrast-enhanced and non-contrast MRI images.
作者信息
Aman Aniket, Hoskote Aaryaman, Jadhav Kshitij S, Aggarwal Bharat
机构信息
Max Super Speciality Hospital, Saket, New Delhi, India.
Indian Institute of Technology - Bombay, Mumbai, Maharashtra, India.
出版信息
Neurosci Lett. 2025 Feb 6;848:138118. doi: 10.1016/j.neulet.2025.138118. Epub 2025 Jan 7.
BACKGROUND
Clinical brain MRI scans, including contrast-enhanced (CE-MR) images, represent an underutilized resource for neuroscience research due to technical heterogeneity.
PURPOSE
To evaluate the reliability of morphometric measurements from CE-MR scans compared to non-contrast MR (NC-MR) scans in normal individuals.
METHODS
T1-weighted CE-MR and NC-MR scans from 59 normal participants (aged 21-73 years) were compared using CAT12 and SynthSeg+ segmentation tools. Volumetric measurements and age prediction efficacy were analyzed.
RESULTS
SynthSeg+ demonstrated high reliability (ICCs > 0.90) for most brain structures between CE-MR and NC-MR scans, with discrepancies in CSF and ventricular volumes. CAT12 showed inconsistent performance. Age prediction models using SynthSeg + yielded comparable results for both scan types.
CONCLUSION
Deep learning-based approaches like SynthSeg+ can reliably process CE-MR scans for morphometric analysis, potentially broadening the application of clinically acquired CE-MR images in neuroimaging research.
背景
由于技术异质性，包括对比增强（CE-MR）图像在内的临床脑部MRI扫描在神经科学研究中是一种未充分利用的资源。
目的
评估正常个体中CE-MR扫描与非对比MR（NC-MR）扫描形态测量的可靠性。
方法
使用CAT12和SynthSeg+分割工具比较了59名正常参与者（年龄21 - 73岁）的T1加权CE-MR和NC-MR扫描。分析了体积测量和年龄预测效能。
结果
对于大多数脑结构，SynthSeg+在CE-MR和NC-MR扫描之间显示出高可靠性（组内相关系数>0.90），脑脊液和脑室体积存在差异。CAT12表现不一致。使用SynthSeg+的年龄预测模型对两种扫描类型产生了可比的结果。
结论
像SynthSeg+这样基于深度学习的方法可以可靠地处理CE-MR扫描以进行形态测量分析，可能会拓宽临床获取的CE-MR图像在神经影像研究中的应用。
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