Li Ruonan, Shang Xin, Zhang Tenglin, Yan Shuxun
Second Ward of Endocrinology Department, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000.
First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou 450000, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024 Jul 28;49(7):1034-1041. doi: 10.11817/j.issn.1672-7347.2024.240280.
Central precocious puberty (CPP) is an endocrine disorder in children caused by the early activation of the hypothalamic-pituitary-gonadal axis (HPGA), leading to elevated gonadotropin-releasing hormone (GnRH), which triggers the development of gonads and the secretion of sex hormones. This eventually results in the development of internal and external genitalia and secondary sexual characteristics. CPP significantly affects the physical and mental health of children and may increase the risk of various adult diseases. The influencing factors and mechanisms of CPP are a central focus of research, and its prevention and treatment remain challenging. Childhood obesity is an important risk factor for CPP, with a complex relationship influenced by endocrine-disrupting chemicals, genetic factors, and epigenetic regulation. The link between the two is primarily related to the regulation of HPGA function by nutritional and metabolic signals. Exploring the relationship between childhood obesity and CPP, along with the potential mechanisms by which obesity induces CPP, can provide theoretical references for identifying new therapeutic targets.
中枢性性早熟（CPP）是一种儿童内分泌疾病，由下丘脑-垂体-性腺轴（HPGA）过早激活引起，导致促性腺激素释放激素（GnRH）升高，进而触发性腺发育和性激素分泌。这最终导致内外生殖器及第二性征发育。CPP严重影响儿童身心健康，并可能增加患各种成人疾病的风险。CPP的影响因素和机制是研究的核心重点，其预防和治疗仍然具有挑战性。儿童肥胖是CPP的一个重要危险因素，二者关系复杂，受内分泌干扰化学物质、遗传因素和表观遗传调控影响。两者之间的联系主要与营养和代谢信号对HPGA功能的调节有关。探索儿童肥胖与CPP之间的关系以及肥胖诱导CPP的潜在机制，可为确定新的治疗靶点提供理论参考。
