He Xin, Lei Meng, Chen Xuewen, Xu Feng, Liu Heng, Wei Zhao
Department of Radiology, Affiliated Hospital of Zunyi Medical University, Engineering Research Center of Intelligent Medical Imaging in Guizhou Higher Education, Zunyi, People's Republic of China.
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.
CNS Neurosci Ther. 2025 Jan;31(1):e70148. doi: 10.1111/cns.70148.
Traumatic brain injury (TBI) is one of the most traumatizing and poses serious health risks to people's bodies due to its unique pathophysiological characteristics. The investigations on the pathological mechanism and valid interventions of TBI have attracted widespread attention worldwide. With bio-mimic mechanic cues, the dynamic hydrogels with dynamic stiffness changes or reversible crosslinking have been suggested to construct the in vitro disease models or novel therapeutic agents for TBI. However, there is a lack of clarification on the dynamic hydrogels currently reported and their biomedical applications on TBI. Our review starts with introducing the native mechanical characters and changes in TBI and then summarizes the common chemical strategies of the dynamic hydrogels with dynamically tunable stiffness and reversible networks for in vitro modeling and therapy. Finally, we prospect the future development of dynamic hydrogels in the mechanical modeling of TBI, providing new mechanical insights for TBI and guidance for tailored brain-targeted biomaterials.
创伤性脑损伤（TBI）是最具创伤性的损伤之一，因其独特的病理生理特征，会对人体健康构成严重风险。对TBI病理机制和有效干预措施的研究已引起全球广泛关注。借助生物模拟力学线索，具有动态刚度变化或可逆交联的动态水凝胶已被建议用于构建TBI的体外疾病模型或新型治疗剂。然而，目前报道的动态水凝胶及其在TBI上的生物医学应用尚缺乏明确说明。我们的综述首先介绍TBI的天然力学特性和变化，然后总结具有动态可调刚度和可逆网络的动态水凝胶用于体外建模和治疗的常见化学策略。最后，我们展望了动态水凝胶在TBI力学建模中的未来发展，为TBI提供新的力学见解，并为定制脑靶向生物材料提供指导。
