皮下脂肪质量和肌肉减少症对结直肠癌患者生存结局的预后影响。

Prognostic impact of subcutaneous fat quality and sarcopenia on the survival outcomes in patients with colorectal cancer.

作者信息

Fujimoto Takaaki, Tamura Koji, Nagayoshi Kinuko, Mizuuchi Yusuke, Okada Yuta, Osajima Satoru, Hisano Kyoko, Horioka Kohei, Shindo Koji, Ikenaga Naoki, Nakata Kohei, Ohuchida Kenoki, Nakamura Masafumi

机构信息

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.

出版信息

Surg Today. 2025 Jan 10. doi: 10.1007/s00595-024-02985-w.

DOI:10.1007/s00595-024-02985-w

PMID:39789347

Abstract

PURPOSE

This study aimed to evaluate the relationship between the quantity and quality of subcutaneous fat and prognosis following colorectal cancer resection.

METHOD

We conducted a retrospective analysis of the clinical data of 399 patients who underwent curative resection for stage 2 or 3 colorectal cancer between January 2013 and March 2019. This study examined the correlation between sarcopenia and various fat parameters, including fat area and density, and assessed their impact on the prognosis.

RESULTS

Sarcopenia was associated with a lower subcutaneous and visceral fat area, higher Hounsfield unit value in subcutaneous fat, and reduced modified intramuscular adipose tissue content in the multifidus, erector spinae, and psoas muscles. A low modified intramuscular adipose tissue content in the multifidus and erector spinae muscles was an independent prognostic factor for overall survival (hazard ratio, 2.28; p = 0.0329) and recurrence-free survival (hazard ratio: 2.32, p = 0.0233). Additionally, subcutaneous fat with a high Hounsfield unit was an independent predictor of a recurrence-free survival (hazard ratio, 2.68; p = 0.0142).

CONCLUSION

Subcutaneous fat quality is correlated with sarcopenia and it thus serves as a prognostic factor for recurrence after stage 2 or 3 colorectal cancer resection.

摘要

目的

本研究旨在评估结直肠癌切除术后皮下脂肪的数量和质量与预后之间的关系。

方法

我们对2013年1月至2019年3月期间接受2期或3期结直肠癌根治性切除的399例患者的临床资料进行了回顾性分析。本研究考察了肌肉减少症与包括脂肪面积和密度在内的各种脂肪参数之间的相关性，并评估了它们对预后的影响。

结果

肌肉减少症与皮下和内脏脂肪面积较低有关，皮下脂肪的亨氏单位值较高，多裂肌、竖脊肌和腰大肌中的改良肌内脂肪组织含量减少。多裂肌和竖脊肌中改良肌内脂肪组织含量低是总生存期（风险比，2.28；p = 0.0329）和无复发生存期（风险比：2.32，p = 0.0233）的独立预后因素。此外，亨氏单位值高的皮下脂肪是无复发生存期的独立预测因素（风险比，2.68；p = 0.0142）。