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新型冠状病毒肺炎对髋关节置换短期预后的影响:一项多中心、回顾性、倾向评分匹配研究

Effects of COVID-19 on short-term outcomes of hip arthroplasty: a multicenter, retrospective, propensity score matched study.

作者信息

Peng Shih-Hui, Lin Yu-Chih, Chang Chih-Hsiang, Hu Chih-Chien, Yang Lan-Yan, Chang Yuhan

机构信息

Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.

College of Medicine, Chang Gung University, Taoyuan, Taiwan.

出版信息

BMC Musculoskelet Disord. 2025 Jan 9;26(1):36. doi: 10.1186/s12891-024-08268-2.

Abstract

PURPOSE

The Coronavirus Disease 2019 (COVID-19) pandemic delayed elective procedures such as total joint arthroplasty. As surgical volumes return to prepandemic levels, understanding the implications of COVID-19 becomes imperative. This study explored the effects of COVID-19 on the short-term outcomes of hip arthroplasty.

METHODS

This multicenter, retrospective, case-control study included patients who had undergone hip arthroplasty between 2020 and 2022. Propensity score matching (PSM) was performed to compare demographic characteristics, primary outcomes, and secondary outcomes between patients with a history of COVID-19 (COVID-19 cohort) and those without it (control cohort). The primary outcomes were surgical site infection, periprosthetic joint infection (PJI), dislocation, prosthesis loosening, deep vein thrombosis, and pulmonary embolism. The secondary outcomes were intraoperative blood loss, nerve injury, renal injury, urinary tract infection (UTI), pneumonia, and acute coronary syndrome.

RESULTS

The COVID-19 and control cohorts comprised 153 and 4925 patients, respectively. After PSM, significant between-cohort differences were observed in the incidence of pneumonia (p < 0.001) and UTI (p = 0.0424). The odds ratio for PJI was 1.62, which is not significant (p = 0.3238) but the culture-negativity rate is higher in the COVID-19 cohort (25%).

CONCLUSION

Our findings suggest that COVID-19 only elevated risks of postoperative pneumonia and UTI after hip arthroplasty. This disease significantly increases the risk of postoperative pneumonia but not of 90-day mortality or any major perioperative complication. On the other hand, PJI still remains a concern because its treatment is challenging owing to its culture-negativity, often necessitating the Girdlestone procedure.

摘要

目的

2019年冠状病毒病(COVID-19)大流行推迟了全关节置换术等择期手术。随着手术量恢复到疫情前水平,了解COVID-19的影响变得至关重要。本研究探讨了COVID-19对髋关节置换术短期预后的影响。

方法

这项多中心、回顾性、病例对照研究纳入了2020年至2022年间接受髋关节置换术的患者。采用倾向评分匹配(PSM)来比较有COVID-19病史的患者(COVID-19队列)和无COVID-19病史的患者(对照组)之间的人口统计学特征、主要结局和次要结局。主要结局包括手术部位感染、假体周围关节感染(PJI)、脱位、假体松动、深静脉血栓形成和肺栓塞。次要结局包括术中失血、神经损伤、肾损伤、尿路感染(UTI)、肺炎和急性冠状动脉综合征。

结果

COVID-19队列和对照组分别包括153例和4925例患者。PSM后,观察到队列间在肺炎发生率(p < 0.001)和UTI发生率(p = 0.0424)方面存在显著差异。PJI的比值比为1.62,无统计学意义(p = 0.3238),但COVID-19队列的培养阴性率更高(25%)。

结论

我们的研究结果表明,COVID-19仅增加了髋关节置换术后肺炎和UTI的风险。这种疾病显著增加了术后肺炎的风险,但未增加90天死亡率或任何主要围手术期并发症的风险。另一方面,PJI仍然是一个问题,因为其培养阴性使其治疗具有挑战性,通常需要进行Girdlestone手术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/408b/11715596/27903b447a51/12891_2024_8268_Figa_HTML.jpg

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