Bernstein Eric F, Wang Jennifer, Eason Chelsea
Main Line Center for Laser Surgery, Ardmore, Pennsylvania, USA.
State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.
Lasers Surg Med. 2025 Feb;57(2):171-176. doi: 10.1002/lsm.23881. Epub 2025 Jan 9.
Poikiloderma of Civatte is a benign skin condition characterized by reticulate erythema and hyperpigmentation in sun-exposed areas, predominantly on the neck, cheeks, and chest. Chronic UV exposure leads to vascular proliferation and red cell extravasation resulting in hemosiderin and melanin deposition. While many light-based modalities have been utilized to treat the disorder, the significant vascularity makes it ideally suited for treatment with vascular lasers.
This study aims to evaluate the safety and efficacy of a new, long-pulse-duration, Nd:YAG laser incorporating a KTP frequency-doubling crystal and cryogen spray cooling for the treatment of Poikiloderma of Civatte.
Twenty subjects with neck and/or chest redness were enrolled in this study and treated using the 532 nm wavelength to treat neck and chest redness. Four treatments were administered at monthly intervals and pre- and 2-month posttreatment images were obtained. Images were randomized and evaluated by three physician evaluators for degree of improvement.
Average improvement 2-months posttreatment were 74.1 ± 20.2% and 68.4 ± 20.5% for the neck and chest, respectively (p < 0.0001). Side effects were minimal and limited to posttreatment erythema, edema, and purpura.
This study demonstrates that this new long pulse-duration, Nd:YAG laser incorporating a KTP frequency-doubling crystal using the 532 nm wavelength is safe and effective for the treatment of Poikiloderma of Civatte.
西瓦特皮肤异色症是一种良性皮肤疾病，其特征为在暴露于阳光下的区域出现网状红斑和色素沉着，主要累及颈部、脸颊和胸部。长期紫外线照射会导致血管增生和红细胞外渗，进而引起含铁血黄素和黑色素沉积。虽然许多光基治疗方法已被用于治疗该疾病，但由于其显著的血管性，使其非常适合用血管激光进行治疗。
本研究旨在评估一种新型长脉冲持续时间、掺钕钇铝石榴石（Nd:YAG）激光（结合磷酸钛氧钾倍频晶体和冷冻喷雾冷却）治疗西瓦特皮肤异色症的安全性和有效性。
本研究纳入了20名有颈部和/或胸部发红症状的受试者，使用532纳米波长治疗颈部和胸部发红。每月进行一次，共进行四次治疗，并在治疗前和治疗后2个月获取图像。图像随机化后由三名医生评估者评估改善程度。
治疗后2个月，颈部和胸部的平均改善率分别为74.1±20.2%和68.4±20.5%（p<0.0001）。副作用极小，仅限于治疗后红斑、水肿和紫癜。
本研究表明，这种新型长脉冲持续时间、结合磷酸钛氧钾倍频晶体的532纳米波长Nd:YAG激光治疗西瓦特皮肤异色症安全有效。
