Guler Senturk Begum, Gurses Bengi, Soyturk Ceren, Copur Sidar, Incir Said, Siriopol Dimitrie, Hasbal Nuri Baris, Akyildiz Murat, van Raalte Daniel H, Kanbay Mehmet
Department of Internal Medicine, Koc University School of Medicine, Istanbul, Turkey.
Department of Radiology, Koc University School of Medicine, Istanbul, Turkey.
Br J Nutr. 2025 Jan 10;133(3):1-10. doi: 10.1017/S0007114525000017.
This interventional single-centre prospective open-label study aims to evaluate the effects of a vegan diet, compared with a vegetarian and omnivorous diet, on metabolic parameters, insulin sensitivity, and liver and kidney steatosis in healthy adults. The study included fifty-three omnivorous participants aged 18-40 years, BMI 18-30 kg/m, without any chronic disease, chronic medication use, active smoking or significant alcohol consumption. All participants were omnivorous at baseline and selected to continue an omnivorous diet or transition to a vegetarian or vegan diet, with follow-up over 6 months. Anthropometric measurements, biochemical parameters and liver and kidney steatosis were assessed at baseline and after six months using MRI-proton density fat fraction. Primary outcomes included changes in liver and kidney steatosis, while secondary outcomes were alterations in anthropometric and biochemical markers. Among fifty-three participants, eighteen followed an omnivorous diet, twenty-one adopted a vegetarian diet and fourteen transitioned to a vegan diet. Dietary interventions did not result in statistically significant changes in BMI, fat mass, fat percentage or muscle mass over 6 months. However, statistically significant improvements in systolic and diastolic blood pressure, favouring the vegan diet, were observed. We aimed to control for potentially confounding variables to ensure the reliability of these findings. We have demonstrated a better decline in steatosis at the lower kidney pole, the total hilus and the Liver 6 index in vegans. We demonstrated that a plant-based diet is associated with improvements in several metabolic parameters and may reduce liver and kidney steatosis.
这项单中心前瞻性开放标签干预性研究旨在评估与素食和杂食饮食相比，纯素饮食对健康成年人代谢参数、胰岛素敏感性以及肝脏和肾脏脂肪变性的影响。该研究纳入了53名年龄在18至40岁之间、体重指数为18至30kg/m²、无任何慢性病、未长期用药、无主动吸烟或大量饮酒的杂食参与者。所有参与者在基线时均为杂食者，并被选择继续杂食饮食或过渡到素食或纯素饮食，随访时间超过6个月。在基线和6个月后使用磁共振成像质子密度脂肪分数评估人体测量学指标、生化参数以及肝脏和肾脏脂肪变性情况。主要结局包括肝脏和肾脏脂肪变性的变化，次要结局是人体测量学和生化指标的改变。在53名参与者中，18人遵循杂食饮食，21人采用素食饮食，14人过渡到纯素饮食。饮食干预在6个月内未导致体重指数、脂肪量、脂肪百分比或肌肉量出现统计学上的显著变化。然而，观察到收缩压和舒张压有统计学上的显著改善，纯素饮食更具优势。我们旨在控制潜在的混杂变量以确保这些发现的可靠性。我们已经证明，纯素饮食者下肾极、肝门总和以及肝脏6指数处的脂肪变性下降更为明显。我们证明，以植物为基础的饮食与多项代谢参数的改善相关，并且可能减少肝脏和肾脏脂肪变性。
