神经炎症与术后认知功能障碍的文献计量分析
Bibliometric Analysis of Neuroinflammation and Postoperative Cognitive Dysfunction.
作者信息
Chen Zheping, Zuo Zhenxiang, Zhang Yizheng, Shan Guoliang, Zhang Le, Gong Moxuan, Ye Yuyang, Ma Yufeng, Jin Yanwu
机构信息
Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Department of Anesthesiology, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.
出版信息
Brain Behav. 2025 Jan;15(1):e70271. doi: 10.1002/brb3.70271.
BACKGROUND
The occurrence and development of postoperative cognitive dysfunction (POCD) are closely linked to neuroinflammation. This bibliometric analysis aims to provide novel insights into the research trajectory, key research topics, and potential future development trends in the field of neuroinflammation-induced POCD.
METHODS
The Web of Science Core Collection (WoSCC) database was searched to identify publications from 2012 to 2023 on neuroinflammation-induced POCD. Bibliometric analysis, involving both statistical and visual analyses, was conducted using CiteSpace, VOSviewer, and the R software.
RESULTS
Research on neuroinflammation-induced POCD has exhibited an increasing trend over the past 12 years. China had the highest number of publications, Nanjing Medical University had the most collaboration with other institutions, Zhiyi Zuo was the most published author, and the Journal of Neuroinflammation served as the primary publication in the field of neuroinflammation-induced POCD. The most frequent keyword was POCD. Keyword clustering analysis indicated that the predominant cluster is dexmedetomidine. Burst detection revealed that postoperative delirium (POD), perioperative neurocognitive disorders (PND), apoptosis, and epigenetic modifications were the future research trends.
CONCLUSIONS
Our analysis identified the following key research areas associated with neuroinflammation-induced POCD: anesthesia, surgery, dexmedetomidine, NLRP3 inflammasome, and mechanism of neuroinflammation-induced POCD. The potential future research topics comprise POD, PND, apoptosis, and epigenetic modifications.
背景
术后认知功能障碍（POCD）的发生与发展与神经炎症密切相关。本文献计量分析旨在为神经炎症诱导的POCD领域的研究轨迹、关键研究主题和未来潜在发展趋势提供新的见解。
方法
检索Web of Science核心合集（WoSCC）数据库，以确定2012年至2023年关于神经炎症诱导的POCD的出版物。使用CiteSpace、VOSviewer和R软件进行文献计量分析，包括统计分析和可视化分析。
结果
在过去12年中，关于神经炎症诱导的POCD的研究呈上升趋势。中国的出版物数量最多，南京医科大学与其他机构的合作最为广泛，左志义是发表文章最多的作者，《神经炎症杂志》是神经炎症诱导的POCD领域的主要出版物。最常见的关键词是POCD。关键词聚类分析表明，主要聚类是右美托咪定。突发检测显示，术后谵妄（POD）、围手术期神经认知障碍（PND）、细胞凋亡和表观遗传修饰是未来的研究趋势。
结论
我们的分析确定了与神经炎症诱导的POCD相关的以下关键研究领域：麻醉、手术、右美托咪定、NLRP3炎性小体和神经炎症诱导的POCD的机制。未来潜在的研究主题包括POD、PND、细胞凋亡和表观遗传修饰。
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