Endothelial activating transcription factor 3 promotes angiogenesis and vascular repair in the mouse retina.

Ischemia and pathological angiogenesis in retinal vascular diseases cause serious vision-related problems. However, the transcriptional regulators of vascular repair remain unidentified. Thus, the factors and mechanisms involved in angiogenesis must be elucidated to develop approaches for restoring normal blood vessels. Here, we investigated the effects of the stress response activating transcription factor 3 () on angiogenesis and vascular regeneration and . was expressed specifically in retinal vascular endothelial cells (ECs) during vascular development. Vascular endothelial growth factor stimulation upregulated expression in cultured ECs. The downregulated expression in ECs caused the deterioration of vascular network formation and . Moreover, deletion in a model of oxygen-induced retinopathy inhibited retinal vascular repair but not pathological neovascularization. Transcriptome analysis confirmed that high expression upregulated the expression of angiogenesis-related genes in ECs. may aid vascular repair therapy in retinal vascular diseases.