Valadez-Cuen Karen, Kozorosky Erica, Farahnik Ferina, Garcia Oscar
Del Sol Medical Center, El Paso, Texas.
Burrell College of Osteopathic Medicine, Las Cruces, NM.
HCA Healthc J Med. 2024 Dec 1;5(6):721-725. doi: 10.36518/2689-0216.1707. eCollection 2024.
Addiction affects millions of people, often resulting from a complex interplay between genetic and environmental factors, and is frequently linked to mental health disorders. Many experts agree there is no cure for addiction, but there are effective treatments available. Many patients continue to succumb to addiction despite treatment. Therefore, more research is needed to develop new therapies in addiction medicine.
This is the case of a 63-year-old woman with an extensive smoking history who suffered an acute stroke affecting her left-sided basal ganglia, including the caudate nucleus and nucleus accumbens. The patient presented with bilateral strokes to the basal ganglia, previously having had a stroke affecting the contralateral basal ganglia. The new stroke resulted in moderate cognitive impairment and personality changes while also resulting in interesting changes to her cigarette addiction. Since the onset of her symptoms, the patient developed an aversion to cigarettes and a curious change in beverage preferences.
This case presents an incidental outcome that highlights what some authors have concluded in their research, which is local ablation to the addiction pathways in the brain can result in decreased rates of addiction in humans.
成瘾影响着数百万人，通常是由遗传和环境因素之间复杂的相互作用导致的，并且常常与精神健康障碍有关。许多专家一致认为成瘾无法治愈，但有有效的治疗方法。尽管接受了治疗，许多患者仍继续屈服于成瘾。因此，需要更多研究来开发成瘾医学的新疗法。
这是一名63岁女性的病例，她有广泛的吸烟史，因急性中风影响了她左侧基底神经节，包括尾状核和伏隔核。该患者双侧基底神经节中风，之前曾有一次中风影响对侧基底神经节。这次新的中风导致中度认知障碍和性格改变，同时也导致了她对香烟成瘾的有趣变化。自症状出现以来，患者对香烟产生了厌恶，并在饮料偏好上发生了奇怪的变化。
本病例呈现了一个偶然的结果，突出了一些作者在其研究中得出的结论，即对大脑中成瘾途径进行局部消融可导致人类成瘾率降低。
