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欧洲疝学会腹疝分类与临床结局评估

Assessment of the European Hernia Society Classification of Ventral Hernias and Clinical Outcomes.

作者信息

Anwoju Oluwatunmininu A, Barrientes Ashtyn, Hogan Connor, Askenasy Erik, Greenberg Jacob, Jerrod Keith, Roth Scott J, Ali Zuhair, Liang Mike K

机构信息

HCA Houston Healthcare Kingwood, Kingwood, TX.

University of Houston, Houston, TX.

出版信息

HCA Healthc J Med. 2024 Dec 1;5(6):649-659. doi: 10.36518/2689-0216.1542. eCollection 2024.

Abstract

BACKGROUND

Ventral hernias are a common but heterogeneous disease. Communication among key stakeholders (eg, patients, clinicians, administrators, payers, and researchers) can be augmented by a widely utilized classification system. The European Hernia Society (EHS) developed an expert-opinion-based hernia classification system organized by hernia type (primary versus incisional) and size. We sought to assess what components of the EHS ventral hernia classification system were correlated to real-world clinical outcomes.

METHODS

This was a multicenter cohort study. All hospitals contributing to the database were affiliated with 1 of 6 academic institutions. All adult patients who underwent ventral hernia repair over a 4-year period were included. The primary endpoint was adverse events defined as any major (deep or organ space) surgical site infection (SSI), abdominal reoperation, or hernia recurrence. Utilizing a multivariable Cox regression, factors associated with adverse events were identified. Accuracy was assessed using Harrell's C concordance statistic.

RESULTS

Of the 2385 patients who underwent repair of ventral hernias (primary n = 810, 34.0% and incisional n = 1575, 66%), with a median follow-up of 11.1 months, 27.5% suffered adverse events including major SSIs (5.7%), hernia recurrences (12.1%), and abdominal reoperations (9.7%). In the overall cohort and the primary ventral hernia subgroup, all hernia-specific variables were associated with adverse events. American Society of Anesthesiologist score, low albumin, and prior SSI were associated with adverse events in the overall cohort and primary ventral hernia subgroup while surgical approach was associated with adverse events in the overall cohort and incisional ventral hernia subgroup. On multivariable Cox regression analyses, incisional ventral hernia and larger hernia width were independently associated with adverse events.

CONCLUSION

Hernia size and type (primary versus incisional) from the EHS ventral hernia classification system were associated with clinical outcomes. Additional factors, including patient and operative factors, also impact outcomes. Our model allows key stakeholders to communicate more clearly regarding the challenges and outcomes of various patients with diverse ventral hernias.

摘要

背景

腹疝是一种常见但异质性的疾病。广泛使用的分类系统可增强关键利益相关者(如患者、临床医生、管理人员、支付方和研究人员)之间的沟通。欧洲疝学会(EHS)制定了一种基于专家意见的疝分类系统,该系统按疝的类型(原发性与切口性)和大小进行组织。我们试图评估EHS腹疝分类系统的哪些组成部分与实际临床结果相关。

方法

这是一项多中心队列研究。所有向数据库贡献数据的医院均隶属于6家学术机构之一。纳入了所有在4年期间接受腹疝修补术的成年患者。主要终点是不良事件,定义为任何严重(深部或器官间隙)手术部位感染(SSI)、腹部再次手术或疝复发。使用多变量Cox回归分析确定与不良事件相关的因素。使用Harrell's C一致性统计量评估准确性。

结果

在2385例接受腹疝修补术的患者中(原发性腹疝810例,占34.0%;切口性腹疝1575例,占66%),中位随访时间为11.1个月,27.5%的患者发生了不良事件,包括严重SSI(5.7%)、疝复发(12.1%)和腹部再次手术(9.7%)。在整个队列和原发性腹疝亚组中,所有疝特异性变量均与不良事件相关。美国麻醉医师协会评分、低白蛋白水平和既往SSI与整个队列和原发性腹疝亚组中的不良事件相关,而手术方式与整个队列和切口性腹疝亚组中的不良事件相关。在多变量Cox回归分析中,切口性腹疝和较大的疝宽度与不良事件独立相关。

结论

EHS腹疝分类系统中的疝大小和类型(原发性与切口性)与临床结果相关。其他因素,包括患者因素和手术因素,也会影响结果。我们的模型使关键利益相关者能够就各种腹疝患者的挑战和结果进行更清晰的沟通。

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