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胰岛素样生长因子结合蛋白5（IGFBP5）在结直肠癌中表达上调并与不良预后相关。

IGFBP5 is Upregulated and Associated with Poor Prognosis in Colorectal Cancer.

作者信息

Deng Yu, Yang Xu, Hua Hongzhong, Zhang Cong

机构信息

Department of Pathology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.

Department of Pathology, Fuyang Hospital of Anhui Medical University, Fuyang, People's Republic of China.

出版信息

Int J Gen Med. 2022 Aug 6;15:6485-6497. doi: 10.2147/IJGM.S370576. eCollection 2022.

DOI:10.2147/IJGM.S370576
PMID:35966504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9365118/
Abstract

PURPOSE

This study aimed to investigate the role of IGFBP5 in colorectal cancer (CRC) and the relationship between the expression of IGFBP5 and clinicopathological parameters in CRC patients.

PATIENTS AND METHODS

Immunohistochemical analysis was used to detect the expression of IGFBP5 and its correlation with clinicopathological parameters of CRC patients. Prognosis analysis, gene set enrichment analysis, and protein interaction network analysis were performed using bioinformatics analysis. The Genomics of Drug Sensitivity in Cancer (GDSC) dataset was used to analyze the correlation between the expression of IGFBP5 and drug resistance.

RESULTS

Immunohistochemical analysis revealed that the expression of IGFBP5 was significantly higher in CRC tissues than in para-cancerous tissues (P < 0.05). High expression of IGFBP5 was associated with tumor differentiation and the N stage of CRC (P < 0.05). Moreover, high expression of IGFBP5 predicted worse overall survival and disease-free survival in CRC patients (P < 0.05). The expression of IGFBP5 was associated with cell-matrix adhesion, extracellular matrix binding, and collagen binding (P < 0.05). Furthermore, IGFBP5 was involved in the Hedgehog signaling pathway and PI3K-Akt signaling pathway (P < 0.05). IGF1, IGF2, SPP1, LTBP1, and FAM20C were most closely related to IGFBP5.

CONCLUSION

The expression of IGFBP5 is upregulated and associated with tumor differentiation, lymph node metastasis, drug resistance, and prognosis in CRC patients.

摘要

目的

本研究旨在探讨胰岛素样生长因子结合蛋白5（IGFBP5）在结直肠癌（CRC）中的作用以及IGFBP5表达与CRC患者临床病理参数之间的关系。

患者与方法

采用免疫组织化学分析检测IGFBP5的表达及其与CRC患者临床病理参数的相关性。使用生物信息学分析进行预后分析、基因集富集分析和蛋白质相互作用网络分析。利用癌症药物敏感性基因组学（GDSC）数据集分析IGFBP5表达与耐药性之间的相关性。

结果

免疫组织化学分析显示，CRC组织中IGFBP5的表达明显高于癌旁组织（P<0.05）。IGFBP5的高表达与CRC的肿瘤分化和N分期相关（P<0.05）。此外，IGFBP5的高表达预示CRC患者的总生存期和无病生存期较差（P<0.05）。IGFBP5的表达与细胞-基质黏附、细胞外基质结合和胶原蛋白结合相关（P<0.05）。此外，IGFBP5参与了刺猬信号通路和PI3K-Akt信号通路（P<0.05）。IGF1、IGF2、SPP1、LTBP1和FAM20C与IGFBP5关系最为密切。

结论

IGFBP5的表达上调，且与CRC患者的肿瘤分化、淋巴结转移、耐药性和预后相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7519/9365118/e5144950adc8/IJGM-15-6485-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7519/9365118/7d7058a3ea9f/IJGM-15-6485-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7519/9365118/693e9af9738d/IJGM-15-6485-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7519/9365118/7884ecc2cfea/IJGM-15-6485-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7519/9365118/54cb3d21cecd/IJGM-15-6485-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7519/9365118/e5144950adc8/IJGM-15-6485-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7519/9365118/7d7058a3ea9f/IJGM-15-6485-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7519/9365118/693e9af9738d/IJGM-15-6485-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7519/9365118/7884ecc2cfea/IJGM-15-6485-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7519/9365118/54cb3d21cecd/IJGM-15-6485-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7519/9365118/e5144950adc8/IJGM-15-6485-g0005.jpg

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