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To what extent is the association between obesity and colorectal cancer risk mediated by systemic inflammation?

作者信息

Safizadeh Fatemeh, Mandic Marko, Hoffmeister Michael, Brenner Hermann

机构信息

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.

出版信息

Cancer Commun (Lond). 2025 Apr;45(4):456-459. doi: 10.1002/cac2.12659. Epub 2025 Jan 10.

DOI:10.1002/cac2.12659
PMID:39791283
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11999883/
Abstract
摘要

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The underestimated impact of excess body weight on colorectal cancer risk: Evidence from the UK Biobank cohort.超重对结直肠癌风险的低估影响：来自英国生物库队列的证据。
Br J Cancer. 2023 Sep;129(5):829-837. doi: 10.1038/s41416-023-02351-6. Epub 2023 Jul 13.
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Association of Overweight, Obesity, and Recent Weight Loss With Colorectal Cancer Risk.超重、肥胖和近期体重减轻与结直肠癌风险的关联。
JAMA Netw Open. 2023 Apr 3;6(4):e239556. doi: 10.1001/jamanetworkopen.2023.9556.
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A preponderance of gastrointestinal cancer patients transition into cachexia syndrome.大量胃肠道癌患者发展为恶病质综合征。
J Cachexia Sarcopenia Muscle. 2022 Dec;13(6):2920-2931. doi: 10.1002/jcsm.13086. Epub 2022 Sep 27.
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Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.阿司匹林用于预防心血管疾病和结直肠癌：美国预防服务工作组的更新证据报告和系统评价。
JAMA. 2022 Apr 26;327(16):1585-1597. doi: 10.1001/jama.2022.3337.
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C-reactive Protein and Future Risk of Clinical and Molecular Subtypes of Colorectal Cancer.C 反应蛋白与结直肠癌临床及分子亚型的未来风险。
Cancer Epidemiol Biomarkers Prev. 2020 Jul;29(7):1482-1491. doi: 10.1158/1055-9965.EPI-19-1339. Epub 2020 Apr 21.
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Adiposity and gastrointestinal cancers: epidemiology, mechanisms and future directions.肥胖与胃肠道癌症：流行病学、发病机制及未来研究方向。
Nat Rev Gastroenterol Hepatol. 2018 Nov;15(11):659-670. doi: 10.1038/s41575-018-0038-1.
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Adiposity and cancer risk: new mechanistic insights from epidemiology.肥胖与癌症风险：来自流行病学的新机制见解。
Nat Rev Cancer. 2015 Aug;15(8):484-98. doi: 10.1038/nrc3967.
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A prospective study of plasma inflammatory markers and risk of colorectal cancer in men.一项前瞻性研究：血浆炎症标志物与男性结直肠癌风险的关系。
Br J Cancer. 2013 May 14;108(9):1891-8. doi: 10.1038/bjc.2013.172. Epub 2013 Apr 16.