Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Br J Cancer. 2013 May 14;108(9):1891-8. doi: 10.1038/bjc.2013.172. Epub 2013 Apr 16.
Chronic inflammation may mediate risk of colorectal cancer (CRC); however, the association between circulating inflammatory markers and risk of CRC has been inconsistent.
We prospectively evaluated the association of plasma C-reactive protein (CRP), interleukin-6 (IL-6), and the soluble tumour necrosis factor receptor 2 (sTNFR-2) with incident CRC among 274 cases and 532 matched controls nested in the Health Professionals Follow-up Study.
Multivariate relative risk (RR) of CRC comparing the extreme quartiles of plasma IL-6 was 1.54 (95% confidence interval (CI), 0.99-2.40; P(trend)=0.02). However, after excluding cases diagnosed within 2 years of blood draw, this association was not statistically significant (RR=1.26, 95% CI, 0.78-2.05; P(trend)=0.21). In analyses restricted to cases diagnosed at least 2 years after blood draw, the association of IL-6 with CRC appeared to differ by body mass index such that the significantly positive association was only present among lean individuals (P(interaction)=0.03). We did not observe any significant association between CRP or sTNFR-2 and CRC.
Plasma inflammatory markers are not generally associated with risk of CRC among men. However, the possibility that plasma IL-6 is associated with increased risk of CRC among lean men requires further investigation.
慢性炎症可能是结直肠癌（CRC）发病风险的一个介导因素；然而，循环炎症标志物与 CRC 发病风险之间的关联并不一致。
我们前瞻性地评估了血浆 C 反应蛋白（CRP）、白细胞介素 6（IL-6）和可溶性肿瘤坏死因子受体 2（sTNFR-2）与健康专业人员随访研究中嵌套的 274 例病例和 532 例匹配对照者中 CRC 发病的相关性。
比较血浆 IL-6 四分位范围极值的 CRC 多变量相对风险（RR）为 1.54（95%置信区间（CI），0.99-2.40；P（趋势）=0.02）。然而，排除了在采血后 2 年内诊断的病例后，这种关联没有统计学意义（RR=1.26，95%CI，0.78-2.05；P（趋势）=0.21）。在仅纳入采血后至少 2 年诊断的病例的分析中，IL-6 与 CRC 的关联似乎因体重指数而异，仅在瘦个体中存在明显的正相关（P（交互作用）=0.03）。我们没有观察到 CRP 或 sTNFR-2 与 CRC 之间有任何显著关联。
血浆炎症标志物一般与男性 CRC 发病风险无关。然而，需要进一步研究血浆 IL-6 是否与瘦男性 CRC 发病风险增加相关。
