Wang Zhuo, Hu Quanhong, Yao Shuncheng, Wang Shaobo, Liu Xi, Zhang Cuiping, Wang Zhong Lin, Li Linlin
Guangzhou Institute of Blue Energy, Knowledge City, Huangpu District, Guangzhou, 510555, P. R. China.
Beijing Key Laboratory of Micro-Nano Energy and Sensor, Center for High-Entropy Energy and Systems, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, P. R. China.
Small. 2025 Feb;21(8):e2409756. doi: 10.1002/smll.202409756. Epub 2025 Jan 10.
Physiological wound healing process can restore the functional and structural integrity of skin, but is often delayed due to external disturbance. The development of methods for promoting the repair process of skin wounds represents a highly desired and challenging goal. Here, a flexible, self-powered, and multifunctional triboelectric nanogenerator (TENG) wound patch (e-patch) is presented for accelerating wound healing through the synergy of electrostimulation and photothermal effect. To fabricate the triboelectric e-patch, a flexible and conductive hydrogel with a dual network of polyacrylamide (PAM) and polydopamine (PDA) is synthesized and doped with multi-walled carbon nanotubes (MCNTs). The hydrogel exhibits high conductivity, good stretchability, and high biocompatibility. The triboelectric e-patch assembled from the hydrogel can detect mechanical and electrical signals of human motions in a real-time manner. In a rodent model of full-thickness dorsal skin wound, the e-patch integrating self-driven electrostimulation and photothermal effect under the near-infrared light irradiation efficiently promotes wound repair and hair follicle regeneration through relieving inflammation, fastening collagen deposition, vascular regeneration, and epithelialization. It offers a promising way to accelerate wound healing.
生理伤口愈合过程能够恢复皮肤的功能和结构完整性，但常常会因外部干扰而延迟。开发促进皮肤伤口修复过程的方法是一个备受期待且具有挑战性的目标。在此，提出了一种柔性、自供电且多功能的摩擦电纳米发电机（TENG）伤口贴片（电子贴片），用于通过电刺激和光热效应的协同作用加速伤口愈合。为了制备摩擦电电子贴片，合成了一种具有聚丙烯酰胺（PAM）和聚多巴胺（PDA）双网络的柔性导电水凝胶，并掺杂了多壁碳纳米管（MCNT）。该水凝胶具有高导电性、良好的拉伸性和高生物相容性。由该水凝胶组装而成的摩擦电电子贴片能够实时检测人体运动的机械和电信号。在全层背部皮肤伤口的啮齿动物模型中，在近红外光照射下集成自驱动电刺激和光热效应的电子贴片通过减轻炎症、加速胶原蛋白沉积、血管再生和上皮形成，有效地促进伤口修复和毛囊再生。它为加速伤口愈合提供了一种有前景的方法。
