Stopka Thomas J, Whitney Bridget M, de Gijsel David, Brook Daniel L, Friedmann Peter D, Taylor Lynn E, Feinberg Judith, Young April M, Evon Donna M, Herink Megan, Westergaard Ryan, Koepke Ruth, Havens Jennifer R, Zule William A, Delaney Joseph A, Pho Mai T
Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA.
Department of Medicine, University of Washington, Seattle, WA.
Med Care. 2025 Feb 1;63(2):77-88. doi: 10.1097/MLR.0000000000002095. Epub 2024 Nov 18.
Restrictive Medicaid policies regarding hepatitis C virus (HCV) treatment may exacerbate rural health care disparities for people who use drugs (PWUD). We assessed associations between Medicaid restrictions and HCV treatment among rural PWUD.
We compiled state-specific Medicaid treatment policies across 8 US rural sites in 10 states and merged these with participant survey data. We hypothesized that local restrictions regarding prescriber type, sobriety, and fibrosis estimates were associated with HCV treatment outcomes. We conducted a cross-sectional, ecological analysis of treatment restrictions and HCV treatment outcomes using bivariate analyses to characterize differences between PWUD who initiated HCV treatment and unadjusted logistic regressions to assess associations between restrictions and treatment.
Among 944 participants, 111 (12%) reported receiving HCV treatment. Participants receiving treatment were older [median age (interquartile range): 42 (34-53) vs. 35 (29-42), P<0.001], more likely to receive disability support (32% vs. 20%, P=0.002), and less likely to be Medicaid-insured (57% vs. 71%, P < 0.001). More PWUD in states without any restrictions reported receiving treatment (17% vs. 11%, P=0.08) and achieving HCV cure/clearance (42% vs. 30%, P=0.01) than in states with restrictions. Restrictions were associated with lower odds of receiving HCV treatment (odds ratio=0.61, 95% CI: 0.35-1.06, P=0.08). Sensitivity analyses showed a similar association with HCV cure/clearance (odds ratio=0.60, 95% CI: 0.40-0.91, P=0.02).
We identified significant unadjusted associations between Medicaid restrictions and receipt of HCV treatment and cure, which has substantial implications for health outcomes among rural PWUD. Lifting remaining Medicaid restrictions will be critical to achieving HCV elimination.
医疗保险与医疗补助服务中心(Medicaid)关于丙型肝炎病毒(HCV)治疗的限制性政策可能会加剧农村地区吸毒者(PWUD)的医疗保健差距。我们评估了Medicaid限制与农村PWUD中HCV治疗之间的关联。
我们汇总了美国10个州8个农村地区特定州的Medicaid治疗政策,并将这些政策与参与者调查数据相结合。我们假设关于开处方者类型、清醒状态和纤维化评估的当地限制与HCV治疗结果相关。我们使用双变量分析对治疗限制和HCV治疗结果进行了横断面生态分析,以描述开始HCV治疗的PWUD之间的差异,并使用未调整的逻辑回归来评估限制与治疗之间的关联。
在944名参与者中,111名(12%)报告接受了HCV治疗。接受治疗的参与者年龄更大[年龄中位数(四分位间距):42岁(34 - 53岁)对35岁(29 - 42岁),P<0.001],更有可能获得残疾支持(32%对20%,P = 0.002),且参加Medicaid保险的可能性更小(57%对71%,P < 0.001)。与有限制的州相比,没有任何限制的州中更多的PWUD报告接受了治疗(17%对11%,P = 0.08)并实现了HCV治愈/清除(42%对30%,P = 0.01)。限制与接受HCV治疗的较低几率相关(优势比 = 0.61,95%置信区间:0.35 - 1.06,P = 0.08)。敏感性分析显示与HCV治愈/清除有类似关联(优势比 = 0.60,95%置信区间:0.40 - 0.91,P = 0.02)。
我们确定了Medicaid限制与接受HCV治疗及治愈之间存在显著的未调整关联,这对农村PWUD的健康结果具有重大影响。取消剩余的Medicaid限制对于实现消除HCV至关重要。