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本文引用的文献

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Nebulized vasopressin penetrates CSF and improves social cognition without inducing aggression in a rhesus monkey model of autism.雾化血管加压素可穿透脑脊液，并改善自闭症恒河猴模型的社会认知，而不会引起攻击行为。
Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2418635121. doi: 10.1073/pnas.2418635121. Epub 2024 Nov 25.
2
Atypical sensory processing features in children with autism, and their relationships with maladaptive behaviors and caregiver strain.自闭症儿童的非典型感觉加工特征及其与适应不良行为和照顾者压力的关系。
Autism Res. 2022 Jun;15(6):1120-1129. doi: 10.1002/aur.2700. Epub 2022 Mar 17.
3
Effects of Intranasal Administration of Oxytocin and Vasopressin on Social Cognition and Potential Routes and Mechanisms of Action.鼻内给予催产素和加压素对社会认知的影响及潜在作用途径和机制
Pharmaceutics. 2022 Jan 29;14(2):323. doi: 10.3390/pharmaceutics14020323.
4
Safety and target engagement of an oral small-molecule sequestrant in adolescents with autism spectrum disorder: an open-label phase 1b/2a trial.一种口服小分子螯合剂在自闭症谱系障碍青少年中的安全性和靶点参与情况：一项开放标签的1b/2a期试验。
Nat Med. 2022 Mar;28(3):528-534. doi: 10.1038/s41591-022-01683-9. Epub 2022 Feb 14.
5
Refining oxytocin therapy for autism: context is key.优化自闭症的催产素疗法：背景是关键。
Nat Rev Neurol. 2022 Feb;18(2):67-68. doi: 10.1038/s41582-021-00602-9.
6
Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder.鼻腔内给予催产素治疗自闭症谱系障碍儿童和青少年。
N Engl J Med. 2021 Oct 14;385(16):1462-1473. doi: 10.1056/NEJMoa2103583.
7
Intranasal vasopressin like oxytocin increases social attention by influencing top-down control, but additionally enhances bottom-up control.鼻内血管加压素类似催产素通过影响自上而下的控制来增加社交注意力，但此外还增强了自下而上的控制。
Psychoneuroendocrinology. 2021 Nov;133:105412. doi: 10.1016/j.psyneuen.2021.105412. Epub 2021 Sep 10.
8
Oxytocin neurons enable social transmission of maternal behaviour.催产素神经元使母婴行为的社会传递成为可能。
Nature. 2021 Aug;596(7873):553-557. doi: 10.1038/s41586-021-03814-7. Epub 2021 Aug 11.
9
Circuits for social learning: A unified model and application to Autism Spectrum Disorder.社交学习电路：统一模型及其在自闭症谱系障碍中的应用。
Neurosci Biobehav Rev. 2019 Dec;107:388-398. doi: 10.1016/j.neubiorev.2019.09.034. Epub 2019 Sep 24.
10
A randomized placebo-controlled pilot trial shows that intranasal vasopressin improves social deficits in children with autism.一项随机安慰剂对照的初步试验表明，鼻内给予血管加压素可改善自闭症儿童的社交障碍。
Sci Transl Med. 2019 May 8;11(491). doi: 10.1126/scitranslmed.aau7356. Epub 2019 May 1.

Development of precision medicine approaches to advance clinical trials for autism and social behavior: A research imperative.

作者信息

Boulton Kelsie A, Guastella Adam J

机构信息

Clinic for Autism and Neurodevelopmental research, Brain and Mind Centre, Children's Hospital Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney 2050, Australia.

Child Neurodevelopment and Mental Health Team, Brain and Mind Centre, University of Sydney, Sydney 2050, Australia.

出版信息

Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2424066122. doi: 10.1073/pnas.2424066122. Epub 2024 Dec 30.

DOI:10.1073/pnas.2424066122
PMID:39793093
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11725788/
Abstract
摘要