Raleigh Joseph S, Culp William T N, Giuffrida Michelle A, Thomson Chris, Martin Tiffany, Mathews Kyle G, Skinner Owen, Leonardi Abby, Bertran Judith, Selmic Laura E, Dornbusch Josephine, Wilson Jordan, Oblak Michelle, Fransson Boel, Lux Cassie N, Wustefeld-Janssens Brandan, Hollenbeck Danielle, Liptak Julius M, Phillips Heidi, Selting Kim A, Park Ji Eun, Wallace Mandy, Steffey Michele A, Balsa Ingrid M, Mayhew Philipp D, Rebhun Robert B, Kent Michael S
1William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA.
2Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA.
J Am Vet Med Assoc. 2025 Jan 10;263(4):1-8. doi: 10.2460/javma.24.10.0642. Print 2025 Apr 1.
To describe the clinical characteristics, treatments, complications, and outcomes in dogs with nasal planum squamous cell carcinoma (SCC) undergoing local treatment.
A retrospective, multi-institutional study was performed. Medical records were searched to identify dogs diagnosed with nasal planum SCC. Variables were recorded from medical records and statistically analyzed.
89 dogs were included. The most common presenting complaint was a visible mass on the nasal planum (89%). Metastasis was detected in 12% of dogs at the time of local therapy. Local therapy consisted of surgical excision alone in 63 of 89 dogs (71%) and radiation therapy alone in 20 of 89 dogs (22%); 6 dogs had multiple local therapies. Tumor size decreased in 12 dogs (60%) undergoing radiation therapy alone. Local recurrence was reported in 19 of 89 dogs (21%), including 16 of 63 dogs (25%) treated with surgery alone. Median survival time of all dogs was 452 days (95% CI, 285 to 576). Median survival time among 33 dogs with documented disease progression was 336 days (95% CI, 189 to 458), versus 685 days (95% CI, 334 to 1,042) in 56 dogs that did not have documented disease progression, which was significantly different (P = .038). Documented disease progression was significantly associated with hazard of death (hazard ratio, 1.93; 95% CI, 1.03 to 3.63; P = .041).
Dogs undergoing local treatment of nasal planum SCC had a favorable prognosis. Metastasis at the time of treatment was uncommon. Long-term survival was possible, particularly in cases without disease progression.
Aggressive local therapy, particularly surgical resection, should be considered in dogs with nasal planum SCC.
描述接受局部治疗的鼻平面鳞状细胞癌（SCC）犬的临床特征、治疗方法、并发症及预后。
进行一项回顾性、多机构研究。检索病历以确定诊断为鼻平面SCC的犬。从病历中记录变量并进行统计学分析。
纳入89只犬。最常见的主诉是鼻平面可见肿物（89%）。12%的犬在局部治疗时检测到转移。局部治疗中，89只犬中有63只（71%）仅接受手术切除，89只犬中有20只（22%）仅接受放射治疗；6只犬接受了多种局部治疗。仅接受放射治疗的12只犬（60%）肿瘤大小减小。89只犬中有19只（21%）出现局部复发，包括仅接受手术治疗的63只犬中的16只（25%）。所有犬的中位生存时间为452天（95%可信区间，285至576天）。33只记录有疾病进展的犬的中位生存时间为336天（95%可信区间，189至458天），而56只未记录有疾病进展的犬的中位生存时间为685天（95%可信区间，334至1042天），差异有统计学意义（P = 0.038）。记录的疾病进展与死亡风险显著相关（风险比，1.93；95%可信区间，1.03至3.63；P = 0.041）。
接受鼻平面SCC局部治疗的犬预后良好。治疗时转移不常见。长期生存是可能的，尤其是在无疾病进展的病例中。
对于鼻平面SCC犬，应考虑积极的局部治疗，尤其是手术切除。
