Readman Megan Rose, Wang Yang, Wan Fang, Fairman Ian, Linkenauger Sally A, Crawford Trevor J, Plack Christopher J
Department of Psychology, Lancaster University, UK; Department of Department of Primary Care and Mental Health, The University of Liverpool, UK; NIHR ARC NWC, Liverpool, UK; Manchester Centre for Audiology and Deafness, The University of Manchester, UK.
Department of Mathematics and Statistics, Lancaster University, UK.
Parkinsonism Relat Disord. 2025 Feb;131:107219. doi: 10.1016/j.parkreldis.2024.107219. Epub 2024 Nov 26.
Hearing impairment is implicated as a risk factor for Parkinson's disease (Parkinson's) incidence, with evidence suggesting that clinically diagnosed hearing loss increases Parkinson's risk 1.5-1.6 fold over 2-5 years follow up. However, the evidence is not unanimous with additional studies observing that self-reported hearing capabilities do not significantly influence Parkinson's incidence. Thus, additional cohort analyses that draw on alternative auditory measures are required to further corroborate the link between Parkinson's and hearing impairment.
To determine whether hearing impairment, estimated using a speech-in-noise test (the Digit Triplet Test, DTT), is a risk factor for Parkinson's incidence.
This was a pre-registered prospective cohort study using data from the UK Biobank. Data pertaining to 159,395 individuals, who underwent DTT testing and were free from Parkinson's at the point of assessment, were analysed. A Cox Proportional Hazard model, controlling for age, sex and educational attainment was conducted.
During a median follow up of 14.24 years, 810 cases of probable Parkinson's were observed. The risk of incident Parkinson's increased with baseline hearing impairment [hazard ratio: 1.57 (95%CI: 1.018, 2.435; P = .041)], indicating 57 % increase in risk for every 10 dB increase in speech-reception threshold (SRT). However, when hearing impairment was categorised in accordance with UK Biobank SRT norms neither 'Insufficient' nor 'Poor' hearing significantly influenced Parkinson's risk compared to 'Normal' hearing.
The congruence of these findings with prior research further supports the existence of a relationship between hearing impairment and Parkinson's incidence.
听力障碍被认为是帕金森病发病的一个风险因素，有证据表明，在2至5年的随访中，临床诊断的听力损失会使帕金森病风险增加1.5至1.6倍。然而，证据并不一致，其他研究发现自我报告的听力能力对帕金森病发病率没有显著影响。因此，需要进行更多利用其他听觉测量方法的队列分析，以进一步证实帕金森病与听力障碍之间的联系。
确定使用噪声言语测试（数字三联体测试，DTT）评估的听力障碍是否是帕金森病发病的风险因素。
这是一项预先注册的前瞻性队列研究，使用英国生物银行的数据。分析了159395名接受DTT测试且在评估时无帕金森病的个体的数据。进行了Cox比例风险模型分析，控制了年龄、性别和教育程度。
在中位随访14.24年期间，观察到810例可能的帕金森病病例。帕金森病发病风险随基线听力障碍增加而升高[风险比：1.57（95%置信区间：1.018，2.435；P = 0.041）]，表明言语接受阈值（SRT）每增加10 dB，风险增加57%。然而，根据英国生物银行SRT规范对听力障碍进行分类时，与“正常”听力相比，“不足”或“差”的听力均未显著影响帕金森病风险。
这些发现与先前研究一致，进一步支持了听力障碍与帕金森病发病率之间存在关联。
