在英国生物银行的82039名参与者中，噪声环境下的听力障碍与新发痴呆症风险增加有关。

Speech-in-noise hearing impairment is associated with an increased risk of incident dementia in 82,039 UK Biobank participants.

作者信息

Stevenson Jonathan S, Clifton Lei, Kuźma Elżbieta, Littlejohns Thomas J

机构信息

Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Albertinen-Haus Centre for Geriatrics and Gerontology, University of Hamburg, Hamburg, Germany.

出版信息

Alzheimers Dement. 2022 Mar;18(3):445-456. doi: 10.1002/alz.12416. Epub 2021 Jul 21.

DOI:10.1002/alz.12416

PMID:34288382

Abstract

INTRODUCTION

Little is known about the association between speech-in-noise (SiN) hearing impairment and dementia.

METHODS

In 82,039 dementia-free participants aged ≥60 years were selected from the UK Biobank. Cox proportional-hazards models were used to investigate whether SiN hearing impairment is associated with an increased risk of incident dementia.

RESULTS

Over 11 years of follow-up (median = 10.1), 1285 participants developed dementia. Insufficient and poor SiN hearing were associated with a 61% (hazard ratio [HR] = 1.61, 95% confidence [CI] 1.41-1.84) and 91% (HR = 1.91, 95% CI 1.55-2.36) increased risk of developing dementia, respectively, compared to normal SiN hearing. The association remained similar when restricting to follow-up intervals of ≤3, >3 to <6, >6 to <9, and >9 years. There was limited evidence for mediation through depressive symptoms and social isolation.

DISCUSSION

SiN hearing impairment is independently associated with incident dementia, providing further evidence for hearing impairment as a potential modifiable dementia risk factor.

摘要

引言

关于噪声环境下言语（SiN）听力障碍与痴呆症之间的关联，目前所知甚少。

方法

从英国生物银行中选取了82039名年龄≥60岁且无痴呆症的参与者。采用Cox比例风险模型来研究SiN听力障碍是否与痴呆症发病风险增加相关。

结果

在超过11年的随访期（中位数 = 10.1）内，1285名参与者患上了痴呆症。与正常SiN听力相比，SiN听力不足和较差分别与痴呆症发病风险增加61%（风险比[HR] = 1.61，95%置信区间[CI] 1.41 - 1.84）和91%（HR = 1.91，95% CI 1.55 - 2.36）相关。当将随访间隔限制在≤3年、>3至<6年、>6至<9年以及>9年时，这种关联仍然相似。通过抑郁症状和社会隔离进行中介的证据有限。