Ayati Firoozabadi Mohammad, Rezaee Hesan, Razzaghof Mohammadreza, Mortazavi Seyed Mohammad Javad
Joint Reconstruction Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Orthopedic Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Joint Reconstruction Research Center (JRRC), Imam Khomeini Hospital, Tehran University of Medical Sciences, End of Keshavarz Blvd, 1419733141 Tehran, Iran.
Int J Surg Case Rep. 2025 Feb;127:110773. doi: 10.1016/j.ijscr.2024.110773. Epub 2024 Dec 31.
Heterotopic ossification (HO) is the formation of mature bone in soft tissue, often occurring after fractures and trauma. Patients with HO experience pain, joint stiffness, and other complications. Treatment aims to improve function; surgical procedures have succeeded in 83.3 % of cases. Existing literature has extensively documented instances of HO occurring in the acetabulum, elbow, and during total hip arthroplasty (THA). HO formation is rare around the knee and intraarticularly after tibia nailing. A unique aspect of our case is the period of restricted ROM in the knee following surgical excision. Additionally, physical therapy played a crucial role in restoring full ROM after this period.
A 38-year-old man presented to our department with right knee pain and restricted ROM resulting from a tibia fracture nailing performed three years earlier in another hospital. Radiographic imaging revealed HO in the retro patellar and intraarticular areas. He underwent surgical excision to remove the HO but continued to experience limited ROM during the follow-up period. Despite undergoing various treatments, including chemoprophylaxis and under anesthesia manipulation, his ROM did not significantly improve. Eventually, after long-term physical therapy, his condition improved, and at the two-year follow-up, he was pain-free with enhanced ROM.
Surgical resection is recommended when HO significantly affects joint range of motion, but incomplete resection is linked to recurrence. After surgical removal of HO, prophylaxis with indomethacin or single fraction radiotherapy is used. However, limitations in range of motion may persist after surgical excision, and recurrence can occur despite preventive measures. Physical therapy may play a crucial role in restoring range of motion and achieving optimal treatment outcomes.
Tibia nailing may contribute to the formation of HO and can lead to a restricted ROM in the knee. It is essential to diagnose HO early and consider a multidisciplinary approach that includes surgical excision, chemoprophylaxis, and physical therapy. The role of physical therapy might be more significant than previously thought.
异位骨化(HO)是指在软组织中形成成熟的骨组织,常发生于骨折和创伤后。患有HO的患者会经历疼痛、关节僵硬及其他并发症。治疗旨在改善功能;手术治疗在83.3%的病例中取得了成功。现有文献广泛记录了HO发生于髋臼、肘部以及全髋关节置换术(THA)期间的病例。HO在膝关节周围及胫骨钉固定术后关节内形成较为罕见。我们这个病例的一个独特之处在于手术切除后膝关节活动范围受限的时期。此外,在此之后物理治疗在恢复完全活动范围方面发挥了关键作用。
一名38岁男性因三年前在另一家医院进行胫骨骨折钉固定术后出现右膝疼痛及活动范围受限前来我院就诊。影像学检查显示髌后及关节内区域存在HO。他接受了手术切除以去除HO,但在随访期间活动范围仍受限。尽管接受了包括化学预防和麻醉下手法操作等各种治疗,其活动范围并未显著改善。最终,经过长期物理治疗,他的病情得到改善,在两年随访时,他已无疼痛且活动范围增大。
当HO显著影响关节活动范围时,建议进行手术切除,但切除不完全与复发有关。HO手术切除后,可使用吲哚美辛预防或单次分割放疗。然而,手术切除后活动范围可能仍会受限,尽管采取了预防措施仍可能复发。物理治疗在恢复活动范围及实现最佳治疗效果方面可能发挥关键作用。
胫骨钉固定可能促成HO的形成,并可导致膝关节活动范围受限。早期诊断HO并考虑采用包括手术切除、化学预防和物理治疗在内的多学科方法至关重要。物理治疗的作用可能比之前认为的更为显著。