Young-Wolff Kelly C, Cortez Catherine A, Nugent Joshua R, Padon Alisa A, Prochaska Judith J, Adams Sara R, Slama Natalie E, Soroosh Aurash J, Does Monique B, Campbell Cynthia I, Ansley Deborah, Castellanos Carley, Brown Qiana L
Division of Research, Kaiser Permanente Northern California, Pleasanton, CA, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
Division of Research, Kaiser Permanente Northern California, Pleasanton, CA, USA.
Drug Alcohol Depend. 2025 Feb 1;267:112546. doi: 10.1016/j.drugalcdep.2024.112546. Epub 2024 Dec 28.
The potential risks of prenatal cannabis use may vary depending on how cannabis is administered, but little is known about modes of prenatal cannabis use. This study characterized prevalence and sociodemographic correlates of modes of prenatal cannabis use in California.
This cross-sectional study included patients with pregnancies between January 1, 2021 and December 31, 2022 in a large healthcare system (3507 pregnancies [3454 individuals]) who self-reported prenatal cannabis use and mode of use (smoke, vape, edibles, dabs, and topicals) during universal screening at entrance to prenatal care. Multivariable regression models examined the relationship between sociodemographic characteristics and modes of use.
Smoking was the most common mode (71.1 %), followed by edibles (32.6 %), vaping (22.2 %), dabs (9.9 %), and topicals (4.6 %); 29.9 % endorsed multiple modes. Those who used edibles were the least likely to use daily (28.2 %), while those who dabbed (54.3 %) or used > 1 mode (45.3 %) were the most likely to use daily. In multivariable models, smoking was generally more common and edibles less common among those who were younger, non-Hispanic Black, and living in more deprived neighborhoods, vaping was more common among Hispanic individuals and less common among non-Hispanic Black individuals and those living in more deprived neighborhoods, and dabbing was more common among those who were younger and Hispanic.
Modes of cannabis use during early pregnancy varied by sociodemographic characteristics. Future research is needed to test whether the risks of adverse outcomes or likelihood of persistent use during pregnancy vary depending on how cannabis is administered during pregnancy.
孕期使用大麻的潜在风险可能因大麻的使用方式而异，但对于孕期大麻的使用方式知之甚少。本研究描述了加利福尼亚州孕期大麻使用方式的患病率及其社会人口学相关因素。
这项横断面研究纳入了2021年1月1日至2022年12月31日期间在一个大型医疗系统中怀孕的患者（3507例妊娠[3454名个体]），这些患者在产前护理入院时的通用筛查中自我报告了孕期大麻使用情况及使用方式（吸烟、吸电子烟、食用大麻制品、浓缩大麻、外用大麻）。多变量回归模型检验了社会人口学特征与使用方式之间的关系。
吸烟是最常见的方式（71.1%），其次是食用大麻制品（32.6%）、吸电子烟（22.2%）、浓缩大麻（9.9%）和外用大麻（4.6%）；29.9%的人认可多种方式。食用大麻制品的人每日使用的可能性最小（28.2%），而使用浓缩大麻的人（54.3%）或使用>1种方式的人（45.3%）每日使用的可能性最大。在多变量模型中，吸烟在年轻人、非西班牙裔黑人以及居住在更贫困社区的人群中通常更为常见，而食用大麻制品则较少见；吸电子烟在西班牙裔个体中更为常见，在非西班牙裔黑人个体以及居住在更贫困社区的人群中较少见；浓缩大麻在年轻人和西班牙裔人群中更为常见。
妊娠早期大麻的使用方式因社会人口学特征而异。未来需要开展研究，以检验不良结局的风险或孕期持续使用的可能性是否因孕期大麻的使用方式不同而有所差异。
