慢性神经源性高血压大鼠的交感肾上腺功能障碍
Sympathoadrenal dysfunction in rats with chronic neurogenic hypertension.
作者信息
Dominiak P, Kees F, Grobecker H
出版信息
Eur J Pharmacol. 1985 Jan 2;107(2):263-6. doi: 10.1016/0014-2999(85)90067-6.
PMID:3979427
Abstract
Compared to sham-operated controls 5 weeks after surgery neurogenic hypertensive rats with sino-aortic baroreceptor deafferentation had higher blood pressure, higher plasma noradrenaline and adrenaline levels, lower heart noradrenaline concentrations, higher adrenomedullary adrenaline levels and increased cardiac intraventricular pressure (dp/dtmax).
摘要
与假手术对照组相比，在手术后5周，去窦主动脉压力感受器的神经源性高血压大鼠血压更高，血浆去甲肾上腺素和肾上腺素水平更高，心脏去甲肾上腺素浓度更低，肾上腺髓质肾上腺素水平更高，心室压力（dp/dtmax）增加。
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