Sabith Nafi Us Sabbir, Rabbani Masud, Alam Kazi Shafiul, Ahamed Sheikh Iqbal
Department of Computer Science, Ubicomp Lab, Marquette University, Milwaukee, WI, USA.
Sci Rep. 2025 Jan 10;15(1):1594. doi: 10.1038/s41598-024-81459-y.
White blood cells (WBCs), also known as leukocytes, are one of the most significant parts of the immune system. They generate antibodies, protect the body from illnesses, and heal wounds. Accurate estimation of WBCs is key for diagnosing cancer, infections, leukemia, lymphoma, and other diseases. However, the widely used Complete Blood Count (CBC) test presents challenges, including prick anxiety, discomfort, and logistical inconvenience to patients. This study introduces a ubiquous White Blood Cell counting system, UbiWhite, a novel smartphone-based, non-invasive system for real-time WBC counting from fingertip videos. Our system uses optical and magnetic techniques to provide accurate WBC counts without blood extraction. An initial experimentation was carried out on 20 adult participants to verify the system's effectiveness compared to standard CBC tests (IRB #4051). The developed algorithms exhibit 1.04 and 1.23 RMSE, respectively. Our innovation provides an easy, affordable, and instantaneous solution for monitoring WBCs in various healthcare settings, including homes and critical care units. Additionally, it serves as a beacon of hope for low- and middle-income nations, where access to and affordability of traditional lab tests are limited.
白细胞(WBCs),也被称为白血球,是免疫系统最重要的组成部分之一。它们产生抗体,保护身体免受疾病侵害,并帮助伤口愈合。准确估计白细胞数量是诊断癌症、感染、白血病、淋巴瘤和其他疾病的关键。然而,广泛使用的全血细胞计数(CBC)测试存在一些挑战,包括针刺焦虑、不适以及给患者带来的后勤不便。本研究介绍了一种无处不在的白细胞计数系统——UbiWhite,这是一种基于智能手机的新型非侵入性系统,用于从指尖视频中实时计数白细胞。我们的系统使用光学和磁性技术,无需采血就能提供准确的白细胞计数。对20名成年参与者进行了初步实验,以验证该系统与标准全血细胞计数测试相比的有效性(机构审查委员会编号#4051)。所开发的算法的均方根误差分别为1.04和1.23。我们的创新为在包括家庭和重症监护病房在内的各种医疗环境中监测白细胞提供了一种简单、经济且即时的解决方案。此外,它为中低收入国家带来了希望之光,因为在这些国家,传统实验室检测的可及性和可承受性有限。