Kowalczyk Iwona, Koziróg Anna, Szulc Adrianna, Komasa Anna, Brycki Bogumił
Department of Bioactive Products, Faculty of Chemistry, Adam Mickiewicz University Poznan, 61-614 Poznan, Poland.
Institute of Fermentation Technology and Microbiology, Faculty of Biotechnology and Food Science, Lodz University of Technology, 90-924 Lodz, Poland.
Molecules. 2025 Jan 3;30(1):164. doi: 10.3390/molecules30010164.
Cationic gemini surfactants are used due to their broad spectrum of activity, especially surface, anticorrosive and antimicrobial properties. Mixtures of cationic and anionic surfactants are also increasingly described. In order to investigate the effect of anionic additive on antimicrobial activity, experimental studies were carried out to obtain MIC (minimal inhibitory concentration) against and bacteria. Two gemini surfactants (12-6-12 and 12-O-12) and two single quaternary ammonium salts (DTAB and DDAC) were analyzed. The most commonly used commercial compounds of this class, i.e., SDS and SL, were used as anionic additives. In addition, computer quantum mechanical studies were also carried out to confirm the relationship between the structure of the mixture and the activity. The obtained results of microbiological tests and quantum mechanical calculations are in agreement with each other and show the lack of synergism in catanionic mixtures in the case of antibacterial activity.
阳离子双子表面活性剂因其广泛的活性，特别是表面活性、防腐和抗菌性能而被使用。阳离子和阴离子表面活性剂的混合物也越来越多地被提及。为了研究阴离子添加剂对抗菌活性的影响，进行了实验研究以获得针对 和 细菌的最低抑菌浓度（MIC）。分析了两种双子表面活性剂（12-6-12和12-O-12）以及两种单季铵盐（DTAB和DDAC）。这类最常用的商业化合物，即SDS和SL，被用作阴离子添加剂。此外，还进行了计算机量子力学研究以证实混合物结构与活性之间的关系。微生物测试和量子力学计算得到的结果相互一致，表明在抗菌活性方面，阴-阳离子混合物缺乏协同作用。
