Thorlacius-Ussing O, Møller-Madsen B, Danscher G
Exp Mol Pathol. 1985 Apr;42(2):278-86. doi: 10.1016/0014-4800(85)90034-6.
A histochemical technique has been used to reveal mercury deposits by light and electron microscopy in the anterior pituitary of adult rats. After administration of mercuric chloride either in the drinking water or by intraperitoneal injection, deposits were found within lysosomes and secretory granules in somatotrophs, thyrotrophs, follicular cells, and marginal cells. The amount of mercury deposited was proportional to the dose of mercuric chloride given. Significantly more mercury was found in rats given intraperitoneal injections compared to those intoxicated with mercuric chloride in the drinking water. Mercury was retained in the cells for at least 4 months after the last injection although the amount of deposits decreased in this period.
已采用一种组织化学技术，通过光学显微镜和电子显微镜揭示成年大鼠垂体前叶中的汞沉积。在通过饮用水或腹腔注射给予氯化汞后，在生长激素细胞、促甲状腺激素细胞、滤泡细胞和边缘细胞的溶酶体和分泌颗粒内发现了沉积物。沉积的汞量与给予的氯化汞剂量成正比。与通过饮用水摄入氯化汞中毒的大鼠相比，腹腔注射的大鼠体内发现的汞明显更多。尽管在此期间沉积物的量有所减少，但在最后一次注射后至少4个月，汞仍保留在细胞中。
