Møller-Madsen B, Thorlacius-Ussing O
Virchows Arch B Cell Pathol Incl Mol Pathol. 1986;51(4):303-11. doi: 10.1007/BF02899039.
A sensitive histochemical technique has been used to visualize the ultrastructural localization of mercury in the anterior pituitary of rats which have been exposed to methyl mercury. After administration of methyl mercury in the drinking water (20 mg X l-1 methyl mercury in distilled water) or intraperitoneally (daily dose 100 ug or 200 ug methyl mercury) intracellular accumulations of mercury were found in the lysosomes and granules of secretory cells (somatotrophs, thyrotrophs and corticotrophs). In non-secretory cells (follicular cell and marginal layer cells) mercury deposits were found in lysosomes. In orally treated rats, the number of mercury deposits increased significantly with time up to day 21. In rats exposed intraperitoneally, a continuous increase was seen in intracellular mercury accumulation. Apart from vacuolation of lysosomes, no structural damage was observed in the cells containing mercury.
一种灵敏的组织化学技术已被用于可视化暴露于甲基汞的大鼠垂体前叶中汞的超微结构定位。在通过饮用水给予甲基汞（蒸馏水中20毫克/升甲基汞）或腹腔注射（每日剂量100微克或200微克甲基汞）后，在分泌细胞（生长激素细胞、促甲状腺激素细胞和促肾上腺皮质激素细胞）的溶酶体和颗粒中发现了细胞内汞积累。在非分泌细胞（滤泡细胞和边缘层细胞）中，汞沉积物存在于溶酶体中。在经口处理的大鼠中，直至第21天，汞沉积物的数量随时间显著增加。在腹腔注射暴露的大鼠中，细胞内汞积累呈持续增加。除了溶酶体空泡化外，在含汞细胞中未观察到结构损伤。
