Berezovskaia I V, Vlasova M E
Farmakol Toksikol. 1985 Jan-Feb;48(1):83-6.
Cytochemical methods were used to explore the changes in the activity of redox (succinate dehydrogenase, mitochondrial alpha-glycerophosphate dehydrogenase) and hydrolytic (acid, alkaline phosphatase, myeloperoxidase) enzymes of peripheral blood leukocytes of random-bred albino rats during simulation of toxic hepato-, nephropathy and hemic hypoxia of different gravity. The studies of the changes of leukocyte distribution according to the activity of the above enzymes were demonstrated to be informative for the diagnosis of prepathological conditions. The possibility was also shown of differentiating the gravity of the pathological conditions with the aid of an analysis of the enzymes under study by the method of linear discriminant functions.
采用细胞化学方法，研究了在模拟不同程度的中毒性肝、肾病及血液性缺氧时，随机繁殖的白化大鼠外周血白细胞中氧化还原酶（琥珀酸脱氢酶、线粒体α-甘油磷酸脱氢酶）和水解酶（酸性、碱性磷酸酶、髓过氧化物酶）活性的变化。结果表明，根据上述酶活性对白细胞分布变化进行研究，对病理前期状态的诊断具有参考价值。通过线性判别函数分析法对所研究的酶进行分析，也显示出区分病理状态严重程度的可能性。
