Berezovskaya I, Beloshapko A, Vlasova M, Kinzyrsky A, Rymartsev V
Arch Toxicol Suppl. 1980;4:187-93. doi: 10.1007/978-3-642-67729-8_41.
Dose-dependent increases in alkaline phosphatase and acid phosphatase activities, decreases in myeloperoxidase activity of neutrophils and depression of lymphocyte glycerophosphate dehydrogenase and succinate dehydrogenase activities were discovered in rat nephropathy induced by mercuric chloride at doses of 0.1-1.0 mg/kg. These changes manifest the intensity of the oxidation-reduction process, the reduction of Kreb's cycle and alpha-glycerophosphatic shunt, the damage by peroxidation and the increase in catabolic processes. The morphometric data of nephron structure reflected the functional cell stress and they were compared with leucocyte enzyme status changes.
在以0.1 - 1.0毫克/千克剂量的氯化汞诱导的大鼠肾病中，发现碱性磷酸酶和酸性磷酸酶活性呈剂量依赖性增加，中性粒细胞的髓过氧化物酶活性降低，淋巴细胞甘油磷酸脱氢酶和琥珀酸脱氢酶活性受到抑制。这些变化表明氧化还原过程的强度、三羧酸循环和α-甘油磷酸分流的减少、过氧化损伤以及分解代谢过程的增加。肾单位结构的形态计量学数据反映了功能性细胞应激，并与白细胞酶状态变化进行了比较。
