Kurmanova Gaukhar, Ayazbekov Ardak, Kurmanova Almagul, Rakhimbayeva Madina, Trimova Gulzhan, Kulembayeva Anarkul
Medicine and Healthcare Faculty, Al Farabi Kazakh National University, 71, Al-Farabi Avenue, 050040 Almaty, Kazakhstan.
Department of Obstetrics and Gynecology, KA Yasawi International Kazakh-Turkish University, 161200 Turkistan, Kazakhstan.
Diagnostics (Basel). 2024 Dec 29;15(1):57. doi: 10.3390/diagnostics15010057.
Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) infection during pregnancy was associated with a number of adverse pregnancy outcomes, including miscarriage, preeclampsia, preterm birth, and stillbirth. The virus persistence can last for a long time, and the consequences of a previous coronavirus infection are currently under study. This study aimed to establish the clinical features of the course of pregnancy and childbirth in women with a history of asymptomatic coronavirus disease 2019 (COVID-19). This study was conducted in the Regional Perinatal Center N3 of Turkestan city, Kazakhstan. A total of 229 participants were enrolled comprising individuals with (n = 133, exposed group) from August to September 2021 with a history of COVID-19 and without one in the same period in 2019 (n = 96, unexposed group). There is a statistically significant strong association between a history of COVID-19 and the development of oligohydramnios (φ = 0.743, < 0.001), and medium strength between a history of COVID-19 and the presence of anemia (φ = 0.254, < 0.001), abnormal development of the placenta (φ = 0.254, < 0.011), cord entanglement (φ = 0.343, = 0.000), low birth weight (φ = 0.356, < 0.001) and stillbirth (φ = 0.293, < 0.001). The past COVID-19 infection in pregnant women has long-term consequences in the form of placenta abnormal development and oligohydramnios; and, as a result, the development of adverse perinatal outcomes.
妊娠期感染严重急性呼吸综合征冠状病毒2(SARS-CoV-2)与多种不良妊娠结局相关,包括流产、子痫前期、早产和死产。病毒持续存在的时间可能很长,先前冠状病毒感染的后果目前正在研究中。本研究旨在确定有2019冠状病毒病(COVID-19)无症状病史的女性在妊娠和分娩过程中的临床特征。本研究在哈萨克斯坦突厥斯坦市第3区域围产期中心进行。共招募了229名参与者,其中包括2021年8月至9月有COVID-19病史的个体(n = 133,暴露组)和2019年同期无COVID-19病史的个体(n = 96,未暴露组)。COVID-19病史与羊水过少的发生之间存在统计学上显著的强关联(φ = 0.743,P < 0.001),与贫血的存在(φ = 0.254,P < 0.001)、胎盘发育异常(φ = 0.254,P < 0.011)、脐带缠绕(φ = 0.343,P = 0.000)、低出生体重(φ = 0.356,P < 0.001)和死产(φ = 0.293,P < 0.001)之间存在中等强度关联。孕妇过去感染COVID-19会产生长期后果,表现为胎盘发育异常和羊水过少;因此,会导致不良围产期结局的发生。