Noor Kaltham Abdulwahid Mohd, Norsuddin Norhashimah Mohd, Isa Iza Nurzawani Che, Abdul Karim Muhammad Khalis
Centre of Diagnostic, Therapeutic and Investigative Studies (CODTIS), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Dubai Health Academic Corporate, Radiology Department, Rashid Hospital, Dubai 00971, United Arab Emirates.
Diagnostics (Basel). 2025 Jan 2;15(1):83. doi: 10.3390/diagnostics15010083.
This study investigated the lifetime attributable risk (LAR) of radiation-induced breast cancer from mammography screening in Dubai. It aimed to explore the relationship between breast thickness, patient age, and the associated radiation dose during mammographic examinations. A retrospective analysis was conducted on 2601 patients aged 40 to 69 across five screening facilities in Dubai's healthcare system. Due to a low correlation between the mean glandular dose (MGD) and breast thickness, both glandular and non-glandular doses were included in calculations as the organ dose (OD). This comprehensive approach examined the impact of whole breast tissue on risk assessments. Key exposure parameters such as the kilovoltage peak (kVp), milliampere-seconds (mAs), and source-to-skin distance were extracted from the dose survey. Our findings reveal that the organ dose increases with breast thickness, emphasizing the need for dose optimization in denser tissues. The LAR decreases with age across all thickness categories, but higher initial LAR values were seen in younger patients with thicker tissue. This study emphasizes the increased sensitivity of younger women, who usually have denser breast tissue, to radiation-induced cancer risks. Personalized screening protocols considering age and breast thickness are crucial for balancing early cancer detection benefits with radiation risks. Future research should improve mammography protocols, explore alternative methods, and consider generic testing for young high-risk patients to mitigate risks while maintaining diagnostic efficacy.
本研究调查了迪拜乳腺钼靶筛查中辐射诱发乳腺癌的终生归因风险（LAR）。其目的是探索乳房厚度、患者年龄以及乳腺钼靶检查期间的相关辐射剂量之间的关系。对迪拜医疗系统中五个筛查机构的2601名年龄在40至69岁之间的患者进行了回顾性分析。由于平均腺体剂量（MGD）与乳房厚度之间的相关性较低，因此在计算中同时纳入了腺体剂量和非腺体剂量作为器官剂量（OD）。这种综合方法考察了整个乳房组织对风险评估的影响。从剂量调查中提取了诸如管电压峰值（kVp）、毫安秒（mAs）和源皮距离等关键暴露参数。我们的研究结果显示，器官剂量随乳房厚度增加而增加，这凸显了对密度较高组织进行剂量优化的必要性。在所有厚度类别中，LAR均随年龄增长而降低，但在乳房组织较厚的年轻患者中，初始LAR值较高。本研究强调了通常乳房组织密度较高的年轻女性对辐射诱发癌症风险的更高敏感性。考虑年龄和乳房厚度的个性化筛查方案对于平衡早期癌症检测益处与辐射风险至关重要。未来的研究应改进乳腺钼靶检查方案，探索替代方法，并考虑对年轻高危患者进行通用检测，以在保持诊断效力的同时降低风险。
