Moreno-Vargas Liliana Marisol, Prada-Gracia Diego
Research Unit on Computational Biology and Drug Design, Children's Hospital of Mexico Federico Gómez, Mexico City 06720, Mexico.
Int J Mol Sci. 2024 Dec 24;26(1):2. doi: 10.3390/ijms26010002.
Cell-penetrating peptides (CPPs) offer a unique and efficient mechanism for delivering therapeutic agents directly into cancer cells. These peptides can traverse cellular membranes, overcoming one of the critical barriers in drug delivery systems. In this review, we explore recent advancements in the application of CPPs for cancer treatment, focusing on mechanisms, delivery strategies, and clinical potential. The review highlights the use of CPP-drug conjugates, CPP-based vaccines, and their role in targeting and inhibiting tumor growth.
细胞穿透肽（CPPs）为将治疗剂直接递送至癌细胞提供了一种独特且高效的机制。这些肽能够穿过细胞膜，克服了药物递送系统中的关键障碍之一。在本综述中，我们探讨了CPPs在癌症治疗应用中的最新进展，重点关注其作用机制、递送策略及临床潜力。该综述强调了CPP-药物偶联物、基于CPPs的疫苗的应用及其在靶向和抑制肿瘤生长中的作用。
