He Kairu, An Feiyu, Zhang Henan, Yan Danli, Li Tong, Wu Junrui, Wu Rina
College of Food Science, Shenyang Agricultural University, Shenyang 110866, China.
Shenyang Key Laboratory of Microbial Fermentation Technology Innovation, Shenyang 110866, China.
Foods. 2024 Dec 25;14(1):23. doi: 10.3390/foods14010023.
, a Gram-negative anaerobic bacterium colonizing the intestinal mucus layer, is regarded as a promising "next-generation probiotic". There is mounting evidence that diabetes and its complications are associated with disorders of abundance. Thus, and its components, including the outer membrane protein Amuc_1100, -derived extracellular vesicles (AmEVs), and the secreted proteins P9 and Amuc_1409, are systematically summarized with respect to mechanisms of action in diabetes mellitus. Diabetes treatments that rely on altering changes in abundance are also reviewed, including the identification of active ingredients, and dietary and pharmacological interventions for abundance. The potential and challenges of using are also highlighted, and it is anticipated that this work will serve as a reference for more in-depth studies on and diabetes development, as well as the creation of new therapeutic targets by colleagues domestically and internationally.
一种定殖于肠道黏液层的革兰氏阴性厌氧菌，被视为一种有前景的“下一代益生菌”。越来越多的证据表明，糖尿病及其并发症与（某种物质）丰度紊乱有关。因此，本文系统总结了（该菌）及其成分，包括外膜蛋白Amuc_1100、（该菌）衍生的细胞外囊泡（AmEVs）以及分泌蛋白P9和Amuc_1409在糖尿病中的作用机制。还综述了依赖改变（某种物质）丰度变化的糖尿病治疗方法，包括（该菌）活性成分的鉴定以及针对（某种物质）丰度的饮食和药物干预。同时也强调了使用（该菌）的潜力和挑战，预计这项工作将为国内外同行对（该菌）与糖尿病发展的更深入研究以及新治疗靶点的创建提供参考。
需注意，原文中部分关键物质未明确写出，翻译时用“（某种物质）”指代，以便呈现完整译文逻辑。
