Hauser C, Wuethrich B, Matter L, Wilhelm J A, Schopfer K
Dermatologica. 1985;170(3):114-20. doi: 10.1159/000249514.
The skin of patients with atopic dermatitis (AD) is severely colonized with Staphylococcus aureus. Therefore, a study was conducted to assess some basic features of the S. aureus-specific immune response in patients with AD and healthy nonatopic individuals. Some particular features were found: a selective hyporesponsiveness to purified S. aureus cell walls (PCW) in delayed skin reactivity; half of our AD patients showed serum IgE to PCW and soluble S. aureus protoplast antigens; elevated PCW-IgE did not correlate with positive immediate skin reactions to whole S. aureus and their cell walls; regional lymphadenopathy but not impetiginization was associated with increased PCW-IgE and high total IgE. It is suggested that these changes in the immune response to S. aureus are related to the chronic S. aureus colonization of the skin.
特应性皮炎（AD）患者的皮肤被金黄色葡萄球菌严重定植。因此，开展了一项研究，以评估AD患者和健康非特应性个体中针对金黄色葡萄球菌的免疫反应的一些基本特征。发现了一些特殊特征：在迟发性皮肤反应中对纯化的金黄色葡萄球菌细胞壁（PCW）存在选择性低反应性；我们一半的AD患者血清中存在针对PCW和可溶性金黄色葡萄球菌原生质体抗原的IgE；PCW-IgE升高与对完整金黄色葡萄球菌及其细胞壁的即时皮肤阳性反应无关；区域性淋巴结病而非脓疱病与PCW-IgE升高和总IgE高水平相关。提示对金黄色葡萄球菌免疫反应的这些变化与皮肤慢性金黄色葡萄球菌定植有关。
