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含协同合生元和低聚果糖可减轻大豆蛋白诱导的小鼠过敏反应。

Synergistic Synbiotic-Containing and Fructo-Oligosaccharide Alleviate the Allergenicity of Mice Induced by Soy Protein.

作者信息

Bai Jing, Zeng Qian, Den Wen, Huang Liheng, Wu Zhihua, Li Xin, Tong Ping, Chen Hongbing, Yang Anshu

机构信息

State Key Laboratory of Food Science and Resources, Nanchang University, Nanjing Dong Lu 235, Nanchang 330047, China.

School of Food Science and Technology, Nanchang University, Nanchang 330047, China.

出版信息

Foods. 2025 Jan 2;14(1):109. doi: 10.3390/foods14010109.

DOI:10.3390/foods14010109
PMID:39796399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11720218/
Abstract

Prebiotics and probiotics have key roles in the intervention and treatment of food allergies. This study assesses the effect of synergistic fructo-oligosaccharide (Lp-FOS) intervention using an allergic mouse model induced by soy protein. The results showed that Lp synergistic FOS significantly decreased clinical allergy scores, inhibited specific antibodies (IgE, IgG, and IgG1), IL-4, IL-6, and IL-17A levels, and increased IFN-γ and IL-10 levels. Meanwhile, flow cytometry showed that Lp-FOS intervention inhibited the percentage of dendritic cell (DC) subsets in splenocytes and increased the Th1/Th2 and Treg/Th17 ratios. Furthermore, Lp-FOS intervention upregulated the mRNA levels of T-bet and Foxp3 and downregulated the mRNA levels of GATA3. Finally, non-targeted metabolomic analysis showed that Lp-FOS improved serum metabolic disorders caused by food allergies through regulating glycine, serine, and threonine metabolism, butanoate metabolism, glyoxylate and dicarboxylate metabolism, the biosynthesis of cofactors, and glycerophospholipid metabolism. These data showed that the combination formulation Lp-FOS could be a promising adjuvant treatment for food allergies.

摘要

益生元和益生菌在食物过敏的干预和治疗中发挥着关键作用。本研究使用大豆蛋白诱导的过敏性小鼠模型评估了协同低聚果糖（Lp-FOS）干预的效果。结果表明，Lp协同FOS显著降低了临床过敏评分，抑制了特异性抗体（IgE、IgG和IgG1）、IL-4、IL-6和IL-17A水平，并提高了IFN-γ和IL-10水平。同时，流式细胞术显示Lp-FOS干预抑制了脾细胞中树突状细胞（DC）亚群的百分比，并提高了Th1/Th2和Treg/Th17比值。此外，Lp-FOS干预上调了T-bet和Foxp3的mRNA水平，下调了GATA3的mRNA水平。最后，非靶向代谢组学分析表明，Lp-FOS通过调节甘氨酸、丝氨酸和苏氨酸代谢、丁酸代谢、乙醛酸和二羧酸代谢、辅因子的生物合成以及甘油磷脂代谢，改善了食物过敏引起的血清代谢紊乱。这些数据表明，联合制剂Lp-FOS可能是一种有前景的食物过敏辅助治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b575/11720218/bd2cfcdc20b8/foods-14-00109-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b575/11720218/e2b7dd50b320/foods-14-00109-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b575/11720218/4e65cfaaa6fe/foods-14-00109-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b575/11720218/57d0b6bf4443/foods-14-00109-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b575/11720218/7d1f666145fd/foods-14-00109-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b575/11720218/026ff1a6f767/foods-14-00109-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b575/11720218/99f20ebf1bd8/foods-14-00109-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b575/11720218/bd2cfcdc20b8/foods-14-00109-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b575/11720218/e2b7dd50b320/foods-14-00109-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b575/11720218/4e65cfaaa6fe/foods-14-00109-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b575/11720218/57d0b6bf4443/foods-14-00109-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b575/11720218/7d1f666145fd/foods-14-00109-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b575/11720218/026ff1a6f767/foods-14-00109-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b575/11720218/99f20ebf1bd8/foods-14-00109-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b575/11720218/bd2cfcdc20b8/foods-14-00109-g007.jpg

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