Effects of on the Differentiation of Intestinal Mucosa Immune Cells and the Composition of Gut Microbiota in Soybean-Sensitized Mice.

In the early stage of this study, three strains of with anti-soybean allergy potential were screened: CICC 6081, subsp. CICC 6103 and subsp. CICC 20988. The aim of this study was to analyze the desensitization effect of three strains of administered by gavage to soybean-allergic mice through the differentiation of immune cells in intestinal lymph nodes and the changes to gut microbiota. The results showed that the three strains of could stimulate the proliferation of dendritic cells (DCs) and regulate the balance of Th1/Th2 differentiation in the MLNs and PPs of soybean-allergic mice. Furthermore, the Th17/Tregs cell-differentiation ratio in the MLNs of the -treated mice was significantly lower than that of the allergic mice ( < 0.05). Compared to the control group, the Shannon, Sobs and Ace indexes of intestinal microbiota in the allergic mice were significantly increased ( < 0.05), and the proportion of was significantly higher ( < 0.05), which was reversed by gavage. In conclusion, the three strains of can inhibit the intestinal mucosal immune response and regulate gut microbiota balance in soybean-allergic mice.