Huang Yan-Yan, Liang Yan-Tong, Wu Jia-Min, Wu Wei-Tong, Liu Xin-Tong, Ye Ting-Ting, Chen Xiao-Rong, Zeng Xin-An, Manzoor Muhammad Faisal, Wang Lang-Hong
College of Food Science and Engineering, Foshan University, Foshan 528225, China.
Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China.
Molecules. 2023 Jan 27;28(3):1242. doi: 10.3390/molecules28031242.
Food allergies are a serious food safety and public health issue. Soybean, dairy, aquatic, poultry, and nut products are common allergens inducing allergic reactions and adverse symptoms such as atopic dermatitis, allergic eczema, allergic asthma, and allergic rhinitis. Probiotics are assumed as an essential ingredient in maintaining intestinal microorganisms' composition. They have unique physiological roles and therapeutic effects in maintaining the mucosal barrier, immune function, and gastrointestinal tract, inhibiting the invasion of pathogenic bacteria, and preventing diarrhea and food allergies. Multiple pieces of evidence reveal a significant disruptive effect of probiotics on food allergy pathology and progression mechanisms. Thus, this review describes the allergenic proteins as an entry point and briefly describes the application of probiotics in allergenic foods. Then, the role of probiotics in preventing and curing allergic diseases by regulating human immunity through intestinal flora and intestinal barrier, modulating host immune active cells, and improving host amino acid metabolism are described in detail. The anti-allergic role of probiotics in the function and metabolism of the gastrointestinal tract has been comprehensively explored to furnish insights for relieving food allergy symptoms and preventing food allergy.
食物过敏是一个严重的食品安全和公共卫生问题。大豆、乳制品、水产品、禽肉和坚果产品是常见的过敏原，可引发过敏反应和不良症状，如特应性皮炎、过敏性湿疹、过敏性哮喘和过敏性鼻炎。益生菌被认为是维持肠道微生物组成的重要成分。它们在维持黏膜屏障、免疫功能和胃肠道、抑制病原菌入侵以及预防腹泻和食物过敏方面具有独特的生理作用和治疗效果。多项证据揭示了益生菌对食物过敏病理和进展机制具有显著的破坏作用。因此，本综述以致敏蛋白为切入点，简要描述了益生菌在致敏食物中的应用。然后，详细阐述了益生菌通过肠道菌群和肠道屏障调节人体免疫力、调节宿主免疫活性细胞以及改善宿主氨基酸代谢来预防和治疗过敏性疾病的作用。全面探讨了益生菌在胃肠道功能和代谢中的抗过敏作用，以为缓解食物过敏症状和预防食物过敏提供见解。
