Perić Iva, Brkljačić Boris, Tadić Tade, Jerković Kristian, Dolić Krešimir, Borić Matija, Ćavar Marija
Department of Diagnostic and Interventional Radiology, University Hospital Split, Spinčićeva 1, 21000 Split, Croatia.
Department of Diagnostic and Interventional Radiology, University Hospital "Dubrava", University of Zagreb School of Medicine, Avenija Gojka Šuška 6, 10000 Zagreb, Croatia.
Cancers (Basel). 2024 Dec 25;17(1):31. doi: 10.3390/cancers17010031.
This study aimed to investigate whether the apparent diffusion coefficient (ADC) maps values of breast lesions presenting as non-mass enhancement (NME) on MRI could predict benign or malignant pathohistological findings.
This retrospective single-center study included 136 female patients with NME and corresponding ultrasound correlate and a subsequent ultrasound-guided core needle biopsy. The patients were subdivided into benign or malignant subgroups based on pathology reports, which served as the gold standard. Blinded to the pathological results, two radiologists independently measured the ADC values of the depicted NME using punctate, 10 mm and whole tumor regions of interest (ROIs) wherever applicable. The mean of all measurements was also analyzed and compared with the pathologic subdivision.
The sensitivity of whole tumor ROI in detecting benign NME is 91% compared to 74% for 10 mm ROI and 78% for punctate ROI. No significant differences in ADC values were observed when comparing fatty breast tissue and dense breast tissue.
There were differences in ADC values between benign and malignant findings using all types of measurements, where the whole tumor ROI was the most sensitive.
本研究旨在探讨磁共振成像（MRI）上表现为非肿块强化（NME）的乳腺病变的表观扩散系数（ADC）图值是否能够预测良性或恶性病理组织学结果。
这项回顾性单中心研究纳入了136例有NME且有相应超声表现并随后接受超声引导下粗针穿刺活检的女性患者。根据作为金标准的病理报告将患者分为良性或恶性亚组。在不知病理结果的情况下，两名放射科医生在适用时分别使用点状、10毫米和整个肿瘤感兴趣区（ROI）独立测量所描绘的NME的ADC值。还分析了所有测量值的平均值并与病理分类进行比较。
整个肿瘤ROI检测良性NME的敏感性为91%，而10毫米ROI为74%，点状ROI为78%。比较脂肪型乳腺组织和致密型乳腺组织时，未观察到ADC值有显著差异。
使用所有类型测量方法时，良性和恶性结果的ADC值存在差异，其中整个肿瘤ROI最为敏感。
