Delorme Josianne, Dima Andra, Bélanger Véronique, Napartuk Mélanie, Bouchard Isabelle, Meloche Caroline, Curnier Daniel, Sultan Serge, Laverdière Caroline, Sinnett Daniel, Marcil Valérie
Centre de Recherche Azrieli du CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Department of Nutrition, Faculty of Medicine, Université de Montreal, Montreal, QC H3T 1A8, Canada.
Cancers (Basel). 2025 Jan 6;17(1):157. doi: 10.3390/cancers17010157.
BACKGROUND/OBJECTIVES: Pediatric cancer survivors are at greater risk of cardiometabolic complications than their peers. This study evaluates the preliminary impact of the VIE (Valorization, Implication, Education) intervention, which integrates nutrition, physical activity, and psychological support, on dietary intake and cardiometabolic health among children and adolescents during cancer treatment.
This comparative study includes pediatric cancer patients recruited to either the VIE intervention group or a control group receiving standard care. Post-treatment data on dietary intake, anthropometric measures, blood pressure, and biochemical parameters were compared between groups and stratified by level of involvement in the nutritional intervention and age at diagnosis (children and adolescents).
In the intervention group, 45 participants were included (51.1% male, mean age at evaluation 10.2 ± 4.5 years, mean time since end of treatment of 1.3 ± 0.8 years), and the control group comprised 77 participants (44.2% male, mean age at evaluation 12.0 ± 5.6 years, mean time since end of treatment of 1.4 ± 0.8 years). The intervention group had lower total caloric intake (mean: 1759 ± 513 vs. 1997 ± 669 kcal, = 0.042) and higher calcium intake (mean: 567 ± 240 vs. 432 ± 197 mg/1000 kcal, = 0.001). The participants who were highly involved in the nutritional intervention had greater protein-derived energy intake than the controls (mean: 17 ± 5 vs. 15 ± 4%, = 0.029). While there was a tendency for a lesser proportion of cardiometabolic risk factors in the adolescents from the intervention group, the differences did not reach statistical significance.
The VIE intervention improved some specific dietary intakes in the medium term after treatment completion but did not significantly impact cardiometabolic health outcomes. Additional strategies are needed to improve the diet of pediatric cancer patients, and further research is warranted to assess the long-term impact of such interventions.
背景/目的：儿童癌症幸存者比同龄人患心脏代谢并发症的风险更高。本研究评估了VIE（增值、参与、教育）干预措施对癌症治疗期间儿童和青少年饮食摄入及心脏代谢健康的初步影响，该干预措施整合了营养、体育活动和心理支持。
这项比较研究纳入了招募到VIE干预组或接受标准护理的对照组的儿科癌症患者。比较两组治疗后的饮食摄入、人体测量指标、血压和生化参数数据，并按营养干预参与程度和诊断时年龄（儿童和青少年）进行分层。
干预组纳入了45名参与者（男性占51.1%，评估时平均年龄10.2±4.5岁，治疗结束后平均时间1.3±0.8年），对照组有77名参与者（男性占44.2%，评估时平均年龄12.0±5.6岁，治疗结束后平均时间1.4±0.8年）。干预组的总热量摄入较低（平均值：1759±513 vs. 1997±669千卡，P=0.042），钙摄入量较高（平均值：567±240 vs. 432±197毫克/1000千卡，P=0.001）。高度参与营养干预的参与者比对照组有更高的蛋白质衍生能量摄入（平均值：17±5 vs. 15±4%，P=0.029）。虽然干预组青少年中存在心脏代谢风险因素的比例有降低趋势，但差异未达到统计学意义。
VIE干预在治疗完成后的中期改善了一些特定的饮食摄入，但对心脏代谢健康结果没有显著影响。需要额外的策略来改善儿科癌症患者的饮食，并且有必要进行进一步研究以评估此类干预的长期影响。
