Andzane Diana, Zodzika Jana, Jermakova Irina, Senfelde Ilva, Utorova Marina, Rezeberga Dace
Gynaecology Clinic, Riga East Clinical University Hospital, Hipokrata Street 2, LV 1079 Riga, Latvia.
Department of Obstetrics and Gynaecology, Rīga Stradiņš University, Miera street 45, LV 1013 Riga, Latvia.
J Clin Med. 2024 Dec 29;14(1):136. doi: 10.3390/jcm14010136.
: The study aimed to investigate the efficacy of medication treatment with glycyrrhizinic acid for cervical intraepithelial neoplasia (CIN) 1 lesions. : Women with histologically confirmed CIN 1 in cervical biopsies were included in the prospective study. Participants of the study group used glycyrrhizinic acid spray (Epigen spray) topically 10 days (Epigen 10-day subgroup) or 20 days (Epigen 20-day subgroup) per month for 6 months. Women in the control group had no treatment. There were two follow-up visits 6 months apart. All patients were screened for human papillomavirus (HPV) before enrollment and during the first follow-up visit. : There were 50 patients in the Epigen group and 50 patients in the control group. At the first follow-up visit, in the histological findings, progression to CIN 2+ was 6.7% in the Epigen 20-day subgroup, 31.1% in the control group, and the persistence of CIN 1 was 86.7% in the Epigen 20-day subgroup and 62.2% in the control group, = 0.03. Large loop excision of the transformation zone (LLETZ) was statistically significantly more frequent in the control group after the first follow-up visit (10% in the Epigen 20-day subgroup vs. 30% in the control group, = 0.032). No such relationships were found during the second follow-up visit. : The vaginal spray of the glycyrrhizinic acid used 20 days per month appears to decrease the risk of the progression of CIN 1 lesions, with the need to perform LLETZ. However, a similar effect is not observed after stopping usage.
该研究旨在探讨甘草酸药物治疗对宫颈上皮内瘤变（CIN）1级病变的疗效。：宫颈活检组织学确诊为CIN 1级的女性被纳入该前瞻性研究。研究组参与者每月局部使用甘草酸喷雾（Epigen喷雾）10天（Epigen 10天亚组）或20天（Epigen 20天亚组），持续6个月。对照组女性不接受治疗。相隔6个月进行两次随访。所有患者在入组前和首次随访时均进行人乳头瘤病毒（HPV）筛查。：Epigen组有50例患者，对照组有50例患者。在首次随访时，组织学检查结果显示，Epigen 20天亚组中进展为CIN 2+的比例为6.7%，对照组为31.1%，Epigen 20天亚组中CIN 1持续存在的比例为86.7%，对照组为62.2%，P = 0.03。首次随访后，对照组进行转化区大环形切除术（LLETZ）的频率在统计学上显著更高（Epigen 20天亚组为10%，对照组为30%，P = 0.032）。在第二次随访时未发现此类关系。：每月使用20天的甘草酸阴道喷雾似乎可降低CIN 1级病变进展的风险，且无需进行LLETZ。然而，停用后未观察到类似效果。
