Poleva Irina
CGH Compagnie Generale des Hopitaux, Rome, Italy.
J Cosmet Dermatol. 2025 Jan;24(1):e16789. doi: 10.1111/jocd.16789.
In recent years, the field of aesthetic dermatology has witnessed a surge in demand for minimally invasive procedures aimed at rejuvenating aging skin. This study aims to address this demand by evaluating the effectiveness of the injectable gel in rejuvenating aging skin, particularly by targeting collagen regeneration and lifting effect.
The study involved 43 participants who underwent three monthly injection sessions targeting retaining ligaments. The injections were administered deeply to ensure proper targeting. Follow-up assessments were conducted after each treatment session and three months after the final injection. Evaluation methods included subjective assessments by both patients and investigators using the Global Aesthetic Improvement Scale (GAIS), as well as objective assessments using a 3D photosystem to measure wrinkle conditions and vectors of traction.
All participants completed the study, with no significant adverse effects observed apart from mild swelling at the injection sites. Despite the high viscosity of HA necessitating the use of a 27 G needle, the injection process was generally comfortable and minimally painful. Subjective evaluations revealed consistent improvements in skin appearance from the first application, which continued to increase throughout the study and remained high even 3 months post-treatment. Objective evaluations demonstrated significant improvements in wrinkle conditions and lifting effects, with a substantial increase in the standard deviation score for wrinkle conditions and the average traction vector length measuring 1.6 mm.
The study findings confirm the safety and efficacy of the injectable formula, with high patient satisfaction, noticeable lifting effects, and significant improvements in wrinkle conditions. These results support the use of the injectable as a promising option for non-invasive skin rejuvenation treatments.
近年来，美容皮肤科领域对旨在使老化皮肤恢复活力的微创治疗的需求激增。本研究旨在通过评估可注射凝胶在使老化皮肤恢复活力方面的有效性来满足这一需求，特别是通过针对胶原蛋白再生和提升效果。
该研究纳入了43名参与者，他们接受了为期三个月、针对固定韧带的注射疗程。注射深度较深以确保准确靶向。每次治疗后以及最后一次注射后三个月进行随访评估。评估方法包括患者和研究人员使用全球美容改善量表（GAIS）进行的主观评估，以及使用三维照相系统测量皱纹状况和牵引向量的客观评估。
所有参与者均完成了研究，除注射部位轻度肿胀外，未观察到明显不良反应。尽管透明质酸的高粘度需要使用27G针头，但注射过程总体舒适且疼痛轻微。主观评估显示，从首次应用开始皮肤外观持续改善，在整个研究过程中持续增加，甚至在治疗后3个月仍保持较高水平。客观评估表明皱纹状况和提升效果有显著改善，皱纹状况的标准差得分大幅增加，平均牵引向量长度为1.6毫米。
研究结果证实了该可注射配方的安全性和有效性，患者满意度高，提升效果显著，皱纹状况有明显改善。这些结果支持将该可注射剂作为非侵入性皮肤年轻化治疗的一个有前景的选择。
